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The influence of spasmolytic agents on heart rate variability and gastrointestinal motility in normal horses.

Author: HarrisonJ L, LesterG D, PhillipsJ K, RaidalS L, SundraT M

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Both propantheline and hyoscine reduced gastrointestinal tract (GIT) sounds and elevated heart rate (HR) in normal horses. Propantheline had a longer duration of effect than hyoscine. Both drugs had marked effects on parasympathetic control of cardiac and GIT function.
Paper Details　
Original Abstract of the Article :
The effects of hyoscine-N-butylbromide (hyoscine) and propantheline-bromide (propantheline) on heart rate (HR), HR variability (HRV) and gastrointestinal tract (GIT) contractions in the normal horse were determined. Five adult horses had ECG recordings for 180 min after treatment with propantheline ...See full text at original site
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引用元：
https://doi.org/10.1016/j.rvsc.2012.05.003

データ提供：米国国立医学図書館（NLM）

The Influence of Spasmolytic Agents on Heart Rate Variability and Gastrointestinal Motility: Exploring the Desert of Physiological Interactions

The human body is a complex and interconnected system, where different organs and systems interact in intricate ways. This study investigates the effects of two spasmolytic agents, hyoscine-N-butylbromide (hyoscine) and propantheline-bromide (propantheline), on heart rate variability (HRV) and gastrointestinal motility in healthy horses.

The researchers studied the effects of these drugs on heart rate, gastrointestinal sounds, and HRV in five horses. They found that both hyoscine and propantheline reduced gastrointestinal sounds and increased heart rate, with propantheline having a longer duration of effect. Additionally, propantheline suppressed HRV, while hyoscine had a more limited effect on HRV.

Understanding the Complex Interplay of Spasmolytic Agents

The study highlights the complex interplay of spasmolytic agents on heart rate and gastrointestinal motility. This knowledge is crucial for understanding the potential side effects of these drugs and for optimizing their use in clinical settings. This is like navigating a desert where the different elements of the environment, such as sand, wind, and water, interact to create a complex and dynamic landscape.

Optimizing Spasmolytic Therapy for Patient Safety

The study's findings emphasize the importance of careful monitoring and dosage adjustments when using spasmolytic agents to ensure patient safety and optimize therapeutic outcomes. This is like navigating a desert with caution, being mindful of potential hazards and adapting to changing conditions.

Dr.Camel's Conclusion

This study provides valuable insights into the effects of spasmolytic agents on heart rate variability and gastrointestinal motility. It underscores the need for careful consideration of their potential effects on multiple organ systems when using them in clinical practice.

Date :
  1. Date Completed 2013-05-30
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

22683390

DOI: Digital Object Identifier

10.1016/j.rvsc.2012.05.003

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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