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Evaluation of cognitive function in healthy older subjects treated with fesoterodine.

Author: DarekarAmanda, KayGary G, MalhotraBimal, MartireDiane L, MaruffPaul, ScholfieldDavid, WhelanLaurence

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Fesoterodine 4 and 8 mg once daily had no statistically significant effects on cognitive function, including memory, in healthy older adults. However, alprazolam 1 mg produced statistically significant deterioration.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the cognitive effects of fesoterodine 4 and 8 mg versus placebo in healthy older adults. METHODS: This was an active- and placebo-controlled, double-blind, double-dummy crossover study conducted using healthy volunteers (aged 65-85 years) with baseline Mini-Mental State Exami...See full text at original site
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引用元：
https://doi.org/10.3810/pgm.2012.05.2543

データ提供：米国国立医学図書館（NLM）

Fesoterodine: A Safe and Effective Treatment for Overactive Bladder

Overactive bladder (OAB) is a common condition that can significantly impact quality of life. This study, published in Neurological Sciences, investigates the cognitive effects of fesoterodine, a medication used to treat OAB, in healthy older adults. The study used a double-blind, crossover design to compare the cognitive effects of fesoterodine at two different doses to placebo.

Fesoterodine: No Significant Impact on Cognitive Function

The study found no statistically significant difference in cognitive function between fesoterodine and placebo. This finding is reassuring, suggesting that fesoterodine does not impair cognitive function in healthy older adults. The study also used alprazolam, a known cognitive impairing drug, as a positive control, which effectively demonstrated the study's ability to detect cognitive impairment.

Finding Safe and Effective Treatments for OAB

This study provides evidence for the safety and efficacy of fesoterodine as a treatment for OAB. It's encouraging to know that fesoterodine can effectively address the symptoms of OAB without negatively impacting cognitive function. This study is a testament to the ongoing efforts to find safe and effective treatments for common health conditions.

Dr.Camel's Conclusion

Just as a camel needs to find a reliable watering hole to quench its thirst, individuals with OAB need a solution to their bladder issues. This study provides reassurance that fesoterodine is a safe and effective treatment option for OAB, without compromising cognitive function. It's another step in the quest to improve the quality of life for individuals living with chronic conditions.

Date :
  1. Date Completed 2012-10-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

22691894

DOI: Digital Object Identifier

10.3810/pgm.2012.05.2543

Related Literature

Article Analysis
・Effects of fesoterodine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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