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Effects of methyldopa on psychometric performance.

Author: ErrichettiA, HochK, JohnsonB, JohnsonJ

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Methyldopa, an antihypertensive medication, was found to impair cognitive function in patients with mild to moderate hypertension. In a double-blind, crossover study of 16 patients, methyldopa significantly reduced blood pressure but also impaired card-sorting time and digital symbol substitution score. Practice effects were greater than those of treatment for all tests except card sorting.
Paper Details　
Original Abstract of the Article :
Double-blind, crossover comparisons of methyldopa with placebo were performed in 16 patients with mild to moderate hypertension. Methyldopa (250 mg tid) for 14 days significantly reduced blood pressure, impaired card-sorting time and digital symbol substitution score, and caused trends for impairmen...See full text at original site
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引用元：
https://doi.org/10.1002/j.1552-4604.1990.tb01852.x

データ提供：米国国立医学図書館（NLM）

Methyldopa's Impact on Cognitive Performance: A Desert of Mental Acuity

This research, like a journey through a desert of mental acuity, explores the effects of methyldopa, a medication used to treat hypertension, on cognitive performance. The authors, like meticulous desert explorers, conducted a double-blind, crossover study to assess the impact of methyldopa on psychometric performance in patients with hypertension. Their findings, like a series of sand dunes, highlight the complex relationship between medication and cognitive function.

Methyldopa's Shadow on Cognitive Performance

This study, like a mirage in the desert, reveals that methyldopa can impair cognitive performance, specifically reducing card-sorting time and digital symbol substitution score. The authors, like astute desert guides, observed that these effects were evident even with moderate dosages of the medication. This finding, like a warning sign in the desert, highlights the importance of monitoring cognitive function in patients taking methyldopa.

Navigating the Desert of Medication: A Need for Vigilance

This research emphasizes the importance of carefully considering the potential cognitive side effects of medications, particularly those used to manage chronic conditions. It's like navigating a desert, where a lack of awareness can lead to unforeseen challenges. This study reminds us that maintaining cognitive function is essential for overall well-being. By being aware of the potential cognitive impact of medications, we can take steps to mitigate risks and support patients in maintaining their mental acuity.

Dr.Camel's Conclusion

This study reminds us that the desert of medication is full of hidden pathways and unexpected challenges. While methyldopa is effective in managing hypertension, it's essential to be mindful of its potential cognitive impact. By navigating the desert of medication with awareness and vigilance, we can support patients in maintaining their cognitive health and overall well-being.
Date :
  1. Date Completed 1991-02-22
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

2273082

DOI: Digital Object Identifier

10.1002/j.1552-4604.1990.tb01852.x

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・Effects of methyldopa
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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