Pharmacokinetics and tolerability of anagrelide hydrochloride in young (18 - 50 years) and elderly (≥ 65 years) patients with essential thrombocythemia.

Author: Alvarez-LarránAlberto, BessesCarlos, CollRuth, FreitagChristian, MartinPatrick, PurkayasthaJaideep, TroySteven, ZellerWolfgang

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To ascertain the role of patient age as an influencing factor in the pharmacokinetics of anagrelide and to clarify whether different dosing is required in young (18 - 50 years) vs. elderly (≥ 65 years) patients with essential thrombocythemia (ET). METHOD: This Phase II, multicenter, open...See full text at original site
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引用元:
https://doi.org/10.5414/CP201711

データ提供:米国国立医学図書館(NLM)

Anagrelide Hydrochloride: Navigating the Desert of Essential Thrombocythemia

Essential thrombocythemia (ET), a rare blood disorder, can pose a significant challenge for patients, often requiring medication to manage platelet levels. This study investigates the pharmacokinetics of anagrelide hydrochloride, a drug used to treat ET, in both young and elderly patients.

The researchers, like experienced camel drivers guiding a caravan across diverse terrains, conducted a study comparing the pharmacokinetics of anagrelide in two age groups. They discovered that while age influenced the pharmacokinetic profile of anagrelide, the differences observed did not warrant a different dosing regimen between young and elderly patients. This reassuring finding, like a reliable oasis providing consistent resources, suggests that anagrelide can effectively manage ET in both age groups.

Anagrelide: A Consistent Oasis for Managing Essential Thrombocythemia

The study's findings, like a well-marked trail across the desert, provide valuable information for healthcare professionals managing ET in patients of different ages. This research suggests that anagrelide can effectively manage ET in both young and elderly individuals, offering a consistent and reliable treatment option.

Health Implications and Applications of Anagrelide

For patients with ET, this research offers a reassuring message, highlighting the effectiveness of anagrelide as a treatment option, regardless of age. It emphasizes the importance of individualized care, considering factors such as age and other health conditions to determine appropriate dosage and treatment strategies. Like a wise camel driver adapting to the terrain, healthcare professionals can navigate the complexities of ET management, ensuring the best possible care for their patients.

Dr.Camel's Conclusion

This research delves into the intricate world of essential thrombocythemia, providing valuable insights into the pharmacokinetics of anagrelide hydrochloride in both young and elderly patients. This study, like a caravan traversing a vast desert, provides reassuring evidence for the effectiveness of anagrelide, offering a beacon of hope for individuals seeking a more comfortable and fulfilling journey through the challenges of ET.

Date :
  1. Date Completed 2012-12-18
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

22943924

DOI: Digital Object Identifier

10.5414/CP201711

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Languages

English

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