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Safety and efficacy of neratinib (HKI-272) plus vinorelbine in the treatment of patients with ErbB2-positive metastatic breast cancer pretreated with anti-HER2 therapy.
Author: AgrapartV, AnanthakrishnanR, AwadaA, DirixL, DiérasV, HershmanD L, LuuT, Manso SanchezL, StaroslawskaE, XuB
Original Abstract of the Article :
BACKGROUND: Neratinib (HKI-272) is a potent irreversible pan-ErbB tyrosine kinase inhibitor with clinical activity in patients with ErbB2/HER2-positive breast cancer. PATIENTS AND METHODS: Phase I of this open-label, phase I/II study investigated the maximum tolerated dose (MTD) of oral neratinib (...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://doi.org/10.1093/annonc/mds284
データ提供:米国国立医学図書館(NLM)
Targeting HER2 in Metastatic Breast Cancer: A New Therapeutic Approach
The battle against breast cancer continues, and researchers are constantly exploring new avenues for effective treatments. This study focuses on the use of neratinib, a potent tyrosine kinase inhibitor, in combination with vinorelbine to target the HER2 protein, a key driver of breast cancer growth. The study investigated the safety and efficacy of this combination therapy in patients with HER2-positive metastatic breast cancer.
Promising Results: Neratinib and Vinorelbine
The study found that the combination of neratinib and vinorelbine showed promising antitumor activity in patients with HER2-positive metastatic breast cancer. This suggests that this combination therapy may be an effective treatment option for patients who have progressed on other therapies. The study also showed that the combination was generally well-tolerated, with manageable side effects.
Hope on the Horizon: A New Weapon in the Fight Against Breast Cancer
This research offers a ray of hope for patients with HER2-positive metastatic breast cancer. The combination of neratinib and vinorelbine represents a potential new weapon in the fight against this challenging disease. It's like finding a new oasis in the vast desert of cancer treatment, offering a beacon of hope for patients and their families.
Dr. Camel's Conclusion
This study highlights the importance of continued research into new therapies for metastatic breast cancer. The combination of neratinib and vinorelbine offers a promising new approach, and further research is needed to explore its full potential. We are constantly searching for new ways to navigate the challenges of cancer, and this research is a step in the right direction.
Date :
- Date Completed 2013-06-20
- Date Revised 2020-02-06
Further Info :
Related Literature
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