Paper Details

  1. Home
  2. Paper Details

Antinociceptive effect of intrathecal loperamide: role of mu-opioid receptor and calcium channels.

Author: KumarRakesh, RaySubrata Basu, ReetaK H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the mechanism of the central analgesic effect of loperamide. The results showed that intrathecally administered loperamide produced analgesia comparable to morphine, but with a longer duration of effect.
Paper Details　
Original Abstract of the Article :
Morphine is a gold standard analgesic commonly used to alleviate pain. However, its use is associated with unavoidable side effects including the risk for addiction. Peripherally administered loperamide lacks effect on the central nervous system as it is a substrate for the permeability glycoprotein...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.ejphar.2012.09.022

データ提供：米国国立医学図書館（NLM）

Antinociceptive Effect of Intrathecal Loperamide: Role of Mu-Opioid Receptor and Calcium Channels

This study investigates the analgesic effect of loperamide, an antidiarrheal drug, when administered intrathecally, directly into the spinal fluid. The researchers utilized experimental methods in rats to examine the mechanisms underlying loperamide's analgesic effect. The primary objective was to determine the role of mu-opioid receptors and calcium channels in loperamide's antinociceptive action.

Loperamide's Analgesic Potential

The study demonstrated that intrathecal loperamide produced analgesic effects comparable to morphine, suggesting its potential as a central analgesic agent. Furthermore, the study revealed that loperamide's analgesic effect was mediated through mu-opioid receptors and subsequent blockade of calcium channels.

New Insights into Loperamide's Action

This study provides valuable insights into the mechanisms underlying loperamide's analgesic action. The findings suggest that loperamide, when administered intrathecally, can act as a potent analgesic, potentially offering a novel therapeutic option for managing pain. Further research is needed to explore the clinical potential of intrathecal loperamide for pain management.

Dr.Camel's Conclusion

Imagine a camel crossing a harsh desert, facing challenging terrain. Just like this camel needs a sturdy saddle for a comfortable ride, patients experiencing pain require effective analgesics for relief. This research explores a novel approach to pain management, suggesting that loperamide, when administered intrathecally, could offer a promising solution for easing discomfort and making the journey less arduous.

Date :
  1. Date Completed 2013-04-17
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

23022331

DOI: Digital Object Identifier

10.1016/j.ejphar.2012.09.022

Related Literature

Article Analysis
・Side Effects of loperamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.