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Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5α-reductase, explaining the need for personalized glucocorticoid and androgen replacement.

Author: AllolioBruno, ArltWiebke, BertagnaXavier, BertheratJérôme, BeuschleinFelix, ChortisVasileios, FassnachtMartin, HahnerStefanie, HughesBeverly A, KaravitakiNiki, LibéRossella, MannelliMassimo, ManteroFranco, NightingalePeter, O'NeilDonna M, OpocherGiuseppe, PorfiriEmilio, QuinklerMarcus, SchneiderPetra, ShackletonCedric H L, SherlockMark, StewartPaul M, TaylorAngela E, TerzoloMassimo, TomlinsonJeremy W

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Mitotane is a medication used to treat metastatic adrenocortical carcinoma. It is considered an adrenolytic substance, which means it can affect the adrenal glands. While the exact effects on steroidogenesis are limited, mitotane treatment is known to cause adrenal insufficiency and male hypogonadism as common side effects.
Paper Details　
Original Abstract of the Article :
Mitotane [1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane] is the first-line treatment for metastatic adrenocortical carcinoma (ACC) and is also regularly used in the adjuvant setting after presumed complete removal of the primary tumor. Mitotane is considered an adrenolytic substance, but ...See full text at original site
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引用元：
https://doi.org/10.1210/jc.2012-2851

データ提供：米国国立医学図書館（NLM）

Mitotane Therapy in Adrenocortical Cancer: Unveiling Steroidogenic Effects

Adrenocortical cancer is a rare but aggressive cancer that affects the adrenal glands. Mitotane is a medication used to treat this cancer, but it can have significant side effects, including adrenal insufficiency and male hypogonadism. This research explores the specific effects of mitotane on steroidogenesis, providing valuable insights into the mechanisms underlying these side effects.

Unraveling the Steroidogenic Effects of Mitotane

This study investigated the specific effects of mitotane on steroidogenesis, the process of hormone production in the adrenal glands. The researchers found that mitotane induces CYP3A4, an enzyme involved in steroid metabolism, and inhibits 5α-reductase, an enzyme involved in androgen production. These findings help explain the development of adrenal insufficiency and male hypogonadism in patients treated with mitotane.

Personalized Management of Mitotane Therapy

This research underscores the importance of personalized management of mitotane therapy. By understanding the specific steroidogenic effects of mitotane, clinicians can better tailor treatment plans to address potential side effects. Just as a camel adapts to the different challenges of the desert, healthcare professionals must adjust their approach based on the individual needs of their patients.

Dr.Camel's Conclusion

This research is like a guidebook through the desert of adrenocortical cancer treatment. By understanding the specific effects of mitotane on steroidogenesis, we can better navigate the challenges of this complex condition and provide personalized care for our patients.
Date :
  1. Date Completed 2013-03-07
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

23162091

DOI: Digital Object Identifier

10.1210/jc.2012-2851

Related Literature

Article Analysis
・Side Effects of mitotane
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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