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[Pharmacovigilance].

Author: BuclinT, LivioF, RenardD

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article summarizes key drug safety updates from 2011. Dronedarone, a heart rhythm drug, was found to have serious side effects for a questionable benefit. Long-term use of proton pump inhibitors (PPIs) was linked to low magnesium levels. Bisphosphonates, osteoporosis medications, were associated with unusual femur fractures. Dasatinib, a cancer drug, was linked to pulmonary arterial hypertension. Lenalidomide, another cancer drug, was linked to secondary cancers. Daptomycin, an antibiotic, was linked to a type of lung inflammation. Tigecycline, another antibiotic, was found to be less effective than other options. Drotrecogin alfa, a treatment for severe sepsis, was withdrawn from the market due to lack of effectiveness. Nimesulide, a pain reliever, was found to be more toxic to the liver than other NSAIDs. Topiramate, an epilepsy medication, was linked to birth defects (oral clefts). Valproate, another epilepsy medication, was linked to cognitive problems in addition to known birth defects. Antipsychotic medications used in late pregnancy were found to increase the risk of complications in newborns.
Paper Details　
Original Abstract of the Article :
Main pharmacovigilance updates in 2011 are reviewed. Dronedarone: Serious cardio-vascular and hepatic adverse reactions for a questionable efficacy. Long-term proton pump inhibitors: A cause of hypomagnesemia. Bisphosphonates: A risk of atypical femoral fractures. Dasatinib: Cases of pulmonary arter...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/23185821

データ提供：米国国立医学図書館（NLM）

Pharmacovigilance: A Vital Watchdog for Drug Safety

The field of [pharmacovigilance] plays a crucial role in ensuring the safety of medications and protecting public health. This review summarizes key pharmacovigilance updates from the year 2011, highlighting important safety concerns associated with various medications.

Safety Concerns and Medication Updates

The review highlights several important safety concerns, including [serious cardiovascular and hepatic adverse reactions associated with dronedarone], [hypomagnesemia related to long-term proton pump inhibitor use], [atypical femoral fractures associated with bisphosphonates], [pulmonary arterial hypertension associated with dasatinib], [second primary malignancies related to lenalidomide], [eosinophilic pneumonia associated with daptomycine], [inferiority of tigecycline to comparators], [market withdrawal of drotrecogin alfa due to lack of efficacy], [higher hepatotoxicity of nimesulide compared to other NSAIDs], [teratogenicity of topiramate], [impaired cognitive development associated with valproate], and [neonatal complications associated with antipsychotics in late pregnancy].

Maintaining Vigilance in Drug Safety

This review emphasizes the ongoing importance of [pharmacovigilance] in identifying and addressing potential drug safety concerns. It highlights the need for continuous monitoring and evaluation of medications to ensure their safe and effective use. Just as a desert traveler needs to be aware of potential hazards and adapt their journey accordingly, so too must healthcare professionals stay informed about the latest pharmacovigilance updates and ensure the safe and effective use of medications.

Dr.Camel's Conclusion

The world of pharmaceuticals, like a vast desert, can hold both treasures and perils. This review provides a valuable snapshot of the ever-evolving landscape of drug safety, highlighting the importance of vigilance and ongoing monitoring to protect public health. It's a reminder that even in the modern era of advanced medicine, the pursuit of safety is a continuous journey, requiring constant vigilance and a commitment to protecting those who rely on medications for their well-being.

Date :
  1. Date Completed 2013-01-18
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

23185821

DOI: Digital Object Identifier

23185821

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in preparation
Languages

French

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