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Current position of phenobarbital in epilepsy and its future.

Author: BrodieMartin J, KwanPatrick

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Phenobarbital is a long-standing epilepsy medication that remains a valuable option, particularly in developing countries. Studies confirm its effectiveness and safety in treating common forms of epilepsy, including childhood seizures and drug-resistant cases. However, recent data link phenobarbital to an increased risk of birth defects in infants of mothers taking the drug. Though some studies suggest potential cognitive and behavioral side effects, others show comparable tolerability to other anti-epileptic drugs and even cognitive improvements due to better seizure control.
Paper Details　
Original Abstract of the Article :
This article reviews the current position of phenobarbital using articles published since 2000 and speculates on its likely future contribution to epilepsy care. Over the last decade there have been no major double-blind randomized placebo-controlled or comparative trials with phenobarbital. Previou...See full text at original site
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引用元：
https://doi.org/10.1111/epi.12027

データ提供：米国国立医学図書館（NLM）

Phenobarbital: A Timeless Remedy in the Desert of Epilepsy

This study delves into the fascinating history of phenobarbital, a venerable antiepileptic drug, exploring its enduring role in epilepsy care. Imagine this as a weathered oasis, a testament to time and experience, providing a sanctuary for those enduring the storms of epilepsy.

The researchers conducted a comprehensive review of the literature, examining the current position of phenobarbital and its likely future contribution to epilepsy management. They sought to understand how this classic remedy continues to serve those facing the challenges of epilepsy.

Phenobarbital's Enduring Legacy: A Timeless Oasis in the Desert

The study found that phenobarbital remains a valuable treatment option, particularly for neonatal and childhood seizures as well as for drug-resistant status epilepticus. It's like a well-established oasis, offering reliable sustenance and respite for those facing the harsh realities of epilepsy.

Navigating the Desert of Epilepsy: A Comprehensive Approach

This study highlights the importance of a comprehensive approach to epilepsy management, drawing upon both traditional and modern therapies. It's like seeking a balance between the wisdom of the ancient oasis and the innovations of modern explorers, seeking the best possible solutions for those traversing the desert of epilepsy.

Dr. Camel's Conclusion

This study, like a tale whispered around a desert campfire, celebrates the enduring legacy of phenobarbital, a testament to its effectiveness and its importance in epilepsy care. It's a reminder that even in the ever-changing desert of medicine, some timeless remedies continue to provide solace and support for those seeking relief.

Date :
  1. Date Completed 2013-02-01
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

23205961

DOI: Digital Object Identifier

10.1111/epi.12027

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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