Developmental changes of brain distribution and localization of oseltamivir and its active metabolite Ro 64-0802 in rats.

Author: KakinumaChihaya, KanoTakashi, MatsumotoNoriko, MorimotoKaori, NagamiTakaaki, OgiharaTakuo, WadaSho

Paper Details 
Original Abstract of the Article :
Oseltamivir, a prodrug of the neuraminidase inhibitor [3R, 4R, 5S]-4-Acetamide-5-amino-3-(1-ethylpropyl)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), is widely used for treatment of influenza infections in Japan, but may be associated with mental instability and suicidal tendencies as a rare ...See full text at original site
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引用元:
https://doi.org/10.2131/jts.37.1217

データ提供:米国国立医学図書館(NLM)

The Intricate Journey of Oseltamivir: Exploring Its Distribution in the Developing Brain

The study delves into the intriguing world of drug distribution in the developing brain, much like a seasoned traveler charting the intricate network of desert pathways. The researchers, like explorers navigating the changing landscape of a desert, investigated the distribution of oseltamivir, a common antiviral medication, in the brains of rats at different ages. They discovered that the concentration of oseltamivir in the brain was highest in young rats and decreased with age. This finding, like discovering a rare oasis that disappears as the desert changes, highlights the importance of understanding how drugs behave in the developing brain.

A Shifting Landscape: Drug Concentration in the Brain

The study's findings, like a shifting sand dune revealing hidden treasures, suggest that oseltamivir may have different effects on the developing brain compared to the adult brain. This information is crucial for understanding the potential risks and benefits of using this medication in young patients. The study's findings, like a compass guiding a traveler, provide valuable information for optimizing drug treatments for young patients.

Health Benefits and Implications

This research emphasizes the importance of considering the unique characteristics of the developing brain when prescribing medications. It highlights the need for caution when using oseltamivir in young patients and emphasizes the importance of further research to understand the long-term implications of drug use during critical developmental stages. This study serves as a reminder that the developing brain is a delicate ecosystem, and careful navigation is crucial for optimal health and well-being.

Dr.Camel's Conclusion

This research, like a guidebook for traversing a vast and ever-changing desert, sheds light on the complex dynamics of drug distribution in the developing brain. The findings highlight the importance of age-specific considerations in medication use and emphasize the need for continuous exploration and understanding of the intricate processes that shape the developing brain. The journey of drug development and patient care requires a meticulous approach, always mindful of the unique characteristics of the traveler and the terrain they are navigating.

Date :
  1. Date Completed 2013-06-21
  2. Date Revised 2019-09-11
Further Info :

Pubmed ID

23208436

DOI: Digital Object Identifier

10.2131/jts.37.1217

Related Literature

SNS
PICO Info
in preparation
Languages

English

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