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Modafinil disrupts prepulse inhibition in mice: strain differences and involvement of dopaminergic and serotonergic activation.

Author: KwekPerrin, van den BuuseMaarten

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effect of modafinil on prepulse inhibition (PPI) in mice, finding that modafinil disrupts PPI in a strain-dependent manner through dopamine D2 and 5-HT2A receptor activation.
Paper Details　
Original Abstract of the Article :
Modafinil is a wakefulness-promoting agent with possible beneficial effects for the management of addiction and in psychiatric conditions, but also with abuse potential of its own. The mechanism of action of modafinil remains unclear. We studied pharmacological mechanisms in the effect of modafinil ...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejphar.2012.11.041

データ提供：米国国立医学図書館（NLM）

Modafinil: A Double-Edged Sword in the Desert of Brain Function

Modafinil, a wakefulness-promoting agent, has shown promise in managing addiction and psychiatric conditions. However, its potential for abuse raises concerns. This study investigates the effects of modafinil on prepulse inhibition (PPI), a model of sensorimotor gating, revealing strain-dependent disruptions in PPI and highlighting the involvement of dopaminergic and serotonergic activation.

Navigating the Desert of Modafinil's Effects: A Complex Landscape of Neurotransmitters

This research delves into the complex effects of modafinil on brain function. The authors' findings suggest that modafinil can disrupt PPI in mice, highlighting the importance of understanding its impact on sensorimotor gating. The study's observations regarding strain-dependent effects and the involvement of dopamine and serotonin pathways provide valuable insights into the mechanisms underlying modafinil's actions.

The Desert of Drug Development: Balancing Benefits and Risks

This study underscores the need for careful consideration of potential risks when developing and using drugs like modafinil. The authors' findings highlight the importance of understanding the complex interactions of modafinil with neurotransmitter systems and its potential impact on sensorimotor gating. This research emphasizes the need for further investigation to clarify the potential benefits and risks of modafinil in clinical settings.

Dr.Camel's Conclusion

This research illuminates the complex and multifaceted nature of modafinil's effects on brain function. The authors' findings suggest that modafinil can disrupt PPI in mice, highlighting the importance of understanding its potential impact on sensorimotor gating and the need for further investigation to clarify its benefits and risks in clinical settings.

Date :
  1. Date Completed 2013-09-02
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

23219987

DOI: Digital Object Identifier

10.1016/j.ejphar.2012.11.041

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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