Food effects on the pharmacokinetics of doxylamine hydrogen succinate 25 mg film-coated tablets: a single-dose, randomized, two-period crossover study in healthy volunteers.

Author: EncinaGregorio, GuibordPascal, LahjouMounia, SansArtur, SicardEric, TolràCarles, VidelaSebastián, XuZhengguo

Paper Details 
Original Abstract of the Article :
Doxylamine succinate, an ethanolamine-based antihistamine, is used in the short-term management of insomnia because of its sedative effects. The data available on the pharmacokinetic profile of doxylamine in humans are limited, notwithstanding that this drug has been marketed in European countries f...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585842/

データ提供:米国国立医学図書館(NLM)

Doxylamine Succinate: Food Effects on Pharmacokinetics

Doxylamine succinate, an antihistamine commonly used for short-term insomnia management, has limited pharmacokinetic data available despite its long history. This study investigates the effect of food on the pharmacokinetic parameters of doxylamine succinate, examining the absorption and metabolism of the drug when administered with or without a meal.

Understanding the Pharmacokinetic Profile of Doxylamine Succinate

This research adds valuable information to our understanding of the pharmacokinetic profile of doxylamine succinate, specifically its interaction with food. The study's findings can guide clinical practice by providing insights into potential adjustments to dosing strategies based on meal timing to optimize therapeutic efficacy.

Navigating the Desert of Sleeplessness

Imagine a desert of sleeplessness, where every restless hour feels like a never-ending trek. This study explores the effects of food on doxylamine succinate, an antihistamine often used for short-term insomnia management. The research provides valuable information about how to optimize its use to ensure a smoother and more effective journey through the desert of insomnia.

Dr.Camel's Conclusion

This research explores the impact of food on the pharmacokinetics of doxylamine succinate, an antihistamine used to treat short-term insomnia. The study's findings provide valuable insights into the drug's absorption and metabolism, potentially guiding clinical practice and optimizing dosing strategies. This research underscores the importance of understanding the interactions between medications and food to ensure safe and effective treatment outcomes.
Date :
  1. Date Completed 2013-08-12
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23230999

DOI: Digital Object Identifier

PMC3585842

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English

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