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Inflammatory bowel diseases and primary sclerosing cholangitis: hepatic and pancreatic side effects due to azathioprine.

Author: AstegianoM, BonaguraA G, CisaròF, PallavicinoF, PellicanoR, ReggianiS, RizzettoM, SguazziniC, SimondiD

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The study investigates the hepato-pancreatic side-effects of azathioprine (AZA) in patients with inflammatory bowel diseases (IBD) and primary sclerosing cholangitis (PSC), an association found in up to 80% of PSC cases.
Paper Details　
Original Abstract of the Article :
In up to 80% of cases primary sclerosing cholangitis (PSC) is associated with inflammatory bowel diseases (IBD). The efficacy of azathioprine (AZA), in the maintenance of remission of IBD has been suggested by several studies. However, AZA tends to exter varied well-known toxicity. Since the rate of...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/23329527

データ提供：米国国立医学図書館（NLM）

A Complex Web: Inflammatory Bowel Diseases, Primary Sclerosing Cholangitis, and Azathioprine

The study of inflammatory bowel diseases (IBD) and primary sclerosing cholangitis (PSC) is like navigating a dense desert, filled with interconnected pathways and potential complications. This research explores the potential for azathioprine (AZA), a commonly used immunosuppressant, to cause hepato-pancreatic side effects in patients with IBD and PSC. The study highlights the importance of carefully monitoring these patients for potential complications, particularly those affecting the liver and pancreas.

Navigating the Desert of IBD and PSC: A Cautious Approach to Azathioprine Treatment

The study underscores the importance of a cautious approach to AZA treatment in patients with IBD and PSC. While AZA can be effective in maintaining remission of IBD, it can also cause a range of side effects, including hepato-pancreatic complications. The study emphasizes the need for careful monitoring of these patients to identify and manage potential adverse events.

The Importance of Vigilance: Managing Potential Side Effects of Azathioprine

This research offers valuable insights for healthcare providers managing patients with IBD and PSC who are receiving AZA treatment. It highlights the importance of monitoring for potential hepato-pancreatic side effects and underscores the need for timely intervention to minimize the risk of complications.

Dr. Camel's Conclusion

The study's findings offer a valuable roadmap for navigating the complexities of IBD and PSC treatment. It emphasizes the importance of careful monitoring and a cautious approach to AZA use in these patients, particularly regarding potential hepato-pancreatic complications.

Date :
  1. Date Completed 2013-06-14
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

23329527

DOI: Digital Object Identifier

23329527

Related Literature

Article Analysis
・Side Effects of azathioprine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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