Effects by silodosin on the partially obstructed rat ureter in vivo and on human and rat isolated ureters.

Author: BenigniF, BuonoR, FossatiN, HedlundP, MontorsiF, RigattiP, VillaL

Paper Details 
Original Abstract of the Article :
α1 -adrenoceptor (-AR) antagonists may facilitate ureter stone passage in humans. We aimed to study effects by the α1 A -AR selective antagonist silodosin (compared to tamsulosin and prazosin) on ureter pressures in a rat model of ureter obstruction, and on contractions of human and rat isolated ure...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632251/

データ提供:米国国立医学図書館(NLM)

Silodosin: A Potential Oasis for Ureteral Obstruction?

Ureteral stones, like pesky grains of sand, can cause discomfort and blockage, creating a roadblock in the urinary tract. Alpha-1 adrenergic receptor (α1-AR) antagonists are often used to help ease the passage of these stones. This study, like a seasoned camel caravan leader, investigates the effectiveness of silodosin, a selective α1A-AR antagonist, in treating ureteral obstruction. The researchers compared the effects of silodosin to other α1-AR antagonists, tamsulosin and prazosin, in a rat model of ureter obstruction. Their findings suggest that silodosin may be a valuable tool for managing ureteral obstruction, potentially providing a smoother path for stone passage.

Silodosin: A Potential Solution for a Common Problem

This research opens the door to new strategies for managing ureteral obstruction, a condition that affects millions of people worldwide. The use of silodosin, based on the promising results of this study, may provide a more effective and less invasive approach to this condition.

Silodosin: A Promise of Relief

Ureteral stones can be a painful and debilitating condition. This research suggests that silodosin could offer a promising solution for those seeking relief from this condition. Remember to consult with your doctor to determine if this medication is appropriate for you.

Dr.Camel's Conclusion

Silodosin is like a refreshing spring in the desert of ureteral obstruction. This study offers a potential solution to a common and often painful problem. It's a reminder that even small discoveries can have a big impact on patients' lives.

Date :
  1. Date Completed 2014-09-05
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23373675

DOI: Digital Object Identifier

PMC3632251

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Languages

English

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