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Piroxicam-β-cyclodextrin: a GI safer piroxicam.

Author: ScarpignatoC

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective but can cause a range of side effects, especially in the gastrointestinal tract. This review discusses the mechanisms of NSAID-induced gastrointestinal damage and explores strategies to reduce these side effects. It highlights piroxicam-beta-cyclodextrin (PBC), a complex form of piroxicam, which is better tolerated than free piroxicam and offers a potentially safer alternative for patients requiring NSAIDs.
Paper Details　
Original Abstract of the Article :
Although NSAIDs are very effective drugs, their use is associated with a broad spectrum of adverse reactions in the liver, kidney, cardiovascular (CV) system, skin and gut. Gastrointestinal (GI) side effects are the most common and constitute a wide clinical spectrum ranging from dyspepsia, heartbur...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664509/

データ提供：米国国立医学図書館（NLM）

Piroxicam-β-cyclodextrin: A Safer Approach to NSAID Therapy

Nonsteroidal anti-inflammatory drugs (NSAIDs), a widely used class of medications, are known for their effectiveness in treating pain and inflammation. However, their use can be accompanied by unwanted side effects, particularly in the gastrointestinal (GI) tract. This research focuses on piroxicam-β-cyclodextrin (PBC), a modified form of the NSAID piroxicam, designed to reduce GI toxicity while maintaining its therapeutic benefits. The study explores the potential of PBC as a safer alternative to traditional NSAIDs.

Piroxicam-β-cyclodextrin: A Safer Option for Pain Relief

The study highlights PBC's improved GI tolerability compared to uncomplexed piroxicam. These findings, like a well-paved path through a desert, suggest that PBC can offer a safer option for patients seeking pain relief without the risk of severe GI side effects.

Navigating the Desert of NSAID Choices

This research provides valuable insights for patients and physicians navigating the complex world of NSAIDs. Just as a wise traveler chooses their path carefully, patients and physicians should consider PBC as a potential alternative, particularly for individuals at risk of GI complications.

Dr.Camel's Conclusion

Piroxicam-β-cyclodextrin, a modified form of the NSAID piroxicam, offers a potential solution to the challenge of GI toxicity associated with traditional NSAIDs. It's like a safe oasis in the desert of pain relief options, providing a more comfortable journey for those seeking pain management.

Date :
  1. Date Completed 2013-11-08
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23394552

DOI: Digital Object Identifier

PMC3664509

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・Side Effects of piroxicam
SNS
PICO Info
in preparation
Languages

English

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