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A combination of cilostazol and Ginkgo biloba extract protects against cisplatin-induced Cochleo-vestibular dysfunction by inhibiting the mitochondrial apoptotic and ERK pathways.

Author: ChoungY-H, KimS W, KimY J, KimY S, LimH J, TianC J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Renexin, a combination of Ginkgo biloba extract and cilostazol, significantly protected against cisplatin-induced cochleo-vestibular dysfunction in rats. This protective effect was greater than that of Ginkgo biloba extract alone and involved inhibiting ROS production, mitochondrial pathways, and the ERK pathway.
Paper Details　
Original Abstract of the Article :
Cisplatin (cis-diammine-dichloroplatinum; CDDP) is an anticancer drug that induces significant hearing loss and balance dysfunction as side effects. Cilostazol (CS, 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3, 4-dihydro-2-(1H)-quinolinone) has neuroprotective and antioxidant effects, whereas Gink...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734837/

データ提供：米国国立医学図書館（NLM）

Protecting Your Ears from the Desert Storm: Cilostazol and Ginkgo Biloba

Cisplatin is a powerful cancer drug, but it can cause significant hearing loss and balance problems. It's like a desert storm that can damage the delicate structures in your inner ear, leaving you with hearing loss and dizziness. This study investigates the protective effects of cilostazol and Ginkgo biloba extract against cisplatin-induced cochleo-vestibular dysfunction.

A Two-Camel Caravan to Protect Your Hearing

Researchers found that a combination of cilostazol and Ginkgo biloba extract, called renexin, was effective at preventing cisplatin-induced hearing loss and balance problems in rats. It’s like sending a two-camel caravan to protect the delicate oasis of your inner ear from the destructive forces of the desert storm.

A New Approach to Protecting Hearing

The study suggests that renexin could be a valuable tool for protecting hearing and balance in cancer patients undergoing cisplatin treatment. It’s like discovering a new shield that can deflect the harmful effects of the desert storm.

Dr.Camel's Conclusion

This study shows that renexin could offer a new approach to preventing cisplatin-induced hearing loss, helping to protect the fragile oasis of our hearing. It’s like finding a new source of water in the desert, providing relief and hope for those facing the challenges of cisplatin treatment.

Date :
  1. Date Completed 2013-06-17
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23429295

DOI: Digital Object Identifier

PMC3734837

Related Literature

Article Analysis
・Side Effects of cilostazol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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