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Ticlopidine with Ginkgo Biloba extract: a feasible combination for patients with acute cerebral ischemia.

Author: HongJi Man, JooIn Soo, LeeJin Soo, LimYoung Ae, ShinDong Hoon

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

The study evaluated the platelet aggregation ability of thienopyridines in relation to various genotypes. Ticlopidine plus Gingko Biloba extract showed sufficient anti-platelet abilities with an acceptable profile of adverse events. CYP2C19 *2 alleles were associated with clopidogrel responsiveness.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Even though clopidogrel is the most used drug for cardiovascular prevention, resistance occurs in significant numbers. Therefore, we evaluated platelet aggregation ability of thienopyridines in relation with various genotypes. METHOD: The study population was randomly assigned with clop...See full text at original site
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引用元：
https://doi.org/10.1016/j.thromres.2013.01.026

データ提供：米国国立医学図書館（NLM）

Ticlopidine and Ginkgo Biloba for Acute Cerebral Ischemia

In the vast desert of cardiovascular research, scientists tirelessly seek ways to prevent and treat the debilitating effects of stroke. This study explores a novel combination therapy for acute cerebral ischemia, involving the antiplatelet agent ticlopidine and the herbal extract Ginkgo biloba. The research investigates the potential of this combination to inhibit platelet aggregation and improve outcomes in patients with acute stroke.

Ticlopidine with Ginkgo Biloba: A Potential Combination for Stroke Treatment

This study provides evidence suggesting that ticlopidine combined with Ginkgo biloba extract may offer significant benefits in inhibiting platelet aggregation in patients with acute cerebral ischemia. The combination demonstrated superior antiplatelet activity compared to ticlopidine alone, particularly in patients with specific genetic variations. These findings warrant further investigation into the potential of this combination therapy in stroke management.

Exploring the Role of Herbal Extracts in Cardiovascular Health

The study's findings highlight the potential of herbal extracts, such as Ginkgo biloba, in supporting cardiovascular health. While further research is necessary to validate the safety and efficacy of this combination therapy, this research offers a promising avenue for exploring alternative and complementary approaches in stroke management. The desert of cardiovascular research continues to yield fascinating discoveries, paving the way for innovative treatments and strategies to combat stroke.

Dr. Camel's Conclusion

This research provides a glimmer of hope in the vast desert of stroke research, suggesting a potential new combination therapy involving ticlopidine and Ginkgo biloba. While further investigation is needed, the promising findings underscore the importance of exploring novel therapeutic approaches to combat stroke and improve patient outcomes.

Date :
  1. Date Completed 2014-02-17
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

23477707

DOI: Digital Object Identifier

10.1016/j.thromres.2013.01.026

Related Literature

Article Analysis
・Side Effects of ticlopidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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