Systemic treatments for basal cell carcinoma (BCC): the advent of dermato-oncology in BCC.

Author: AliF R, LearJ T

Paper Details 
Original Abstract of the Article :
Basal cell carcinoma (BCC) is the most common cancer in the U.K. and its incidence is increasing. Vismodegib, a hedgehog pathway inhibitor, has recently been licensed by the U.S. Food and Drug Administration for treatment of advanced BCC. Phase 2 trials have demonstrated efficacy in cases of locally...See full text at original site
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引用元:
https://doi.org/10.1111/bjd.12311

データ提供:米国国立医学図書館(NLM)

Vismodegib: A New Frontier in Basal Cell Carcinoma Treatment?

Basal cell carcinoma (BCC), the most common type of skin cancer, presents a significant challenge for healthcare professionals. This research examines the emergence of vismodegib, a hedgehog pathway inhibitor, as a novel treatment option for advanced BCC. The researchers review the clinical trial data on vismodegib, evaluating its effectiveness in managing locally advanced, metastatic, and hereditary forms of BCC. The study also discusses the potential side effects and limitations of vismodegib therapy, highlighting the need for ongoing research to optimize its use and explore alternative treatment strategies. This research provides valuable insights into the evolving landscape of BCC treatment, offering hope for new therapies and improved outcomes for patients.

Vismodegib Shows Promise in Advanced BCC Treatment

Clinical trials have demonstrated the effectiveness of vismodegib in managing advanced BCC, particularly in cases of locally advanced, metastatic, and hereditary forms of the disease. This represents a significant advance in the treatment of BCC, offering new hope for patients with aggressive forms of the disease. The study's findings highlight the potential of vismodegib as a targeted therapy, specifically inhibiting the hedgehog pathway, which plays a crucial role in the development and progression of BCC. This targeted approach offers a potential advantage over traditional therapies, leading to more effective treatment outcomes and a reduced risk of side effects.

Navigating the Desert of BCC Treatment

This research offers a promising new path through the desert of BCC treatment. It's like discovering a hidden oasis of potential therapies, offering hope for patients with this common and often challenging skin cancer. However, it's important to recognize that vismodegib therapy comes with potential side effects and limitations. Further research is crucial to refine treatment strategies, minimize side effects, and explore alternative treatment options. The study's findings highlight the importance of ongoing research and innovation in the quest for more effective and safe treatment options for BCC.

Dr.Camel's Conclusion

The emergence of vismodegib as a novel treatment for BCC represents a significant step forward in the battle against this common skin cancer. It's like finding a hidden oasis of therapeutic potential in the vast desert of BCC research. While vismodegib offers promise, continued research is essential to optimize its use, minimize side effects, and explore alternative treatment approaches.

Date :
  1. Date Completed 2014-01-29
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

23488543

DOI: Digital Object Identifier

10.1111/bjd.12311

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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