Paper Details

  1. Home
  2. Paper Details

Expanding role of pharmacogenomics in the management of cardiovascular disorders.

Author: PirmohamedMunir, YipVincent Lai Ming

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Pharmacogenetics aims to personalize cardiovascular medications by considering genetic variations that influence drug response and side effects. Warfarin, an anticoagulant, is an example where genetic testing is used to optimize dosage. Aspirin and clopidogrel, antiplatelet drugs, are also being studied for their pharmacogenetic applications but findings are not yet conclusive. Statins, commonly used to lower cholesterol, have been linked to several genetic variations but more research is needed to determine their impact on cardiovascular outcomes. ACE inhibitors and beta-blockers, used for hypertension and heart failure, also show potential for pharmacogenetic personalization but require further investigation. Overall, pharmacogenetics has the potential to improve cardiovascular care by tailoring medications to individual patients, but more research is needed to develop clinically validated tests.
Paper Details　
Original Abstract of the Article :
Cardiovascular disease is a leading cause of death worldwide. Many pharmacologic therapies are available that aim to reduce the risk of cardiovascular disease but there is significant inter-individual variation in drug response, including both efficacy and toxicity. Pharmacogenetics aims to personal...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s40256-013-0024-5

データ提供：米国国立医学図書館（NLM）

Pharmacogenomics: Tailoring Treatments for a Better Heart

This research explores the growing field of [pharmacogenomics], which aims to personalize medication choice and dosage based on an individual's genetic makeup. The authors focus on the application of pharmacogenomics in the management of [cardiovascular disorders], highlighting the potential for improving treatment outcomes and minimizing adverse effects. They discuss specific examples of how genetic variations can influence drug response, including [anticoagulant warfarin, anti-platelet therapy, and statin therapy].

Unveiling the Genetic Code of Cardiovascular Treatment

The authors discuss the role of [genetic polymorphisms] in influencing drug response and the potential for using this information to optimize treatment for cardiovascular disorders. They emphasize the importance of considering [cytochrome P450 (CYP) enzymes] and other genes involved in drug metabolism and action. It's like deciphering a complex genetic code to unlock the secrets of individual drug response.

A Desert of Genetic Variations: Navigating Individualized Care

This research highlights the significant potential of pharmacogenomics in transforming cardiovascular care. By considering the genetic makeup of individual patients, clinicians can potentially tailor treatment strategies for more effective and safer outcomes. It's like navigating a vast and complex desert of genetic variations, seeking to find the right path for each individual's unique needs.

Dr.Camel's Conclusion

This review discusses the expanding role of pharmacogenomics in the management of cardiovascular disorders. The authors emphasize the potential for personalized medicine to improve treatment outcomes and minimize adverse effects, highlighting the importance of understanding the genetic basis of drug response.

Date :
  1. Date Completed 2014-01-22
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

23579966

DOI: Digital Object Identifier

10.1007/s40256-013-0024-5

Related Literature

Article Analysis
・Side Effects of perindopril
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.