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Noninvasive prenatal testing creates an opportunity for antenatal treatment of Down syndrome.

Author: BianchiDiana W, GuedjFaycal

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Trisomy 21 (T21), the most common autosomal aneuploidy associated with intellectual disability, is targeted by prenatal screening programs globally. While pregnant women have the option to continue or terminate the pregnancy, no fetal treatment is currently available. This article reviews studies suggesting a potential window of opportunity during fetal life to positively impact brain development and improve postnatal neurocognition and behavior. While understanding the neurobiology of Down syndrome (DS) has advanced, most pre-clinical trials focus on adults. The challenges in developing antenatal therapies include ensuring safety for both mother and fetus, demonstrating placental crossing and therapeutic levels, and proving clinical improvement. Preliminary experiments in mouse models suggest prenatal treatment for DS is achievable.
Paper Details　
Original Abstract of the Article :
Trisomy 21 (T21) is the most common autosomal aneuploidy that is associated with intellectual disability. It is the focus of many prenatal screening programs across the globe. Pregnant women who receive a prenatal diagnosis of T21 in their fetus currently have the option of continuing or terminating...See full text at original site
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引用元：
https://doi.org/10.1002/pd.4134

データ提供：米国国立医学図書館（NLM）

Antenatal Treatment for Down Syndrome: A Camel's Journey Through the Desert of Developmental Potential

Down syndrome (DS), like a unique oasis in the vast desert of human development, presents both challenges and opportunities. This research explores the potential for antenatal treatment of DS, a condition associated with intellectual disability. The researchers review compelling morphogenetic, cellular, and molecular studies that suggest a critical window of opportunity during fetal life to positively impact brain development and improve postnatal neurocognition and behavior. While challenges exist in developing safe and effective antenatal therapies for DS, preliminary experiments in mouse models offer hope for a future where prenatal intervention could improve the lives of individuals with DS.

Exploring the Frontiers of Prenatal Treatment: A Camel's Guide to Optimizing Developmental Potential

This research presents a compelling case for the potential of antenatal treatment for DS. The findings suggest that interventions during fetal life could have a significant impact on brain development and cognitive function. While more research is needed, the potential for improving the lives of individuals with DS is both exciting and promising.

A Camel's Perspective on Developmental Potential: The Importance of Early Intervention

Early intervention, like a well-timed oasis on a long desert journey, can make a profound difference in the lives of individuals with developmental differences. This research highlights the potential for antenatal treatment to optimize developmental potential and improve the lives of individuals with DS. By exploring the possibilities of early intervention, we can create a more inclusive and supportive society for individuals with developmental disabilities.

Dr. Camel's Conclusion

This research offers a beacon of hope for individuals with DS and their families. The potential for antenatal treatment, though still in its early stages, holds immense promise for improving the lives of individuals with DS. As we continue to explore the vast desert of developmental research, we gain valuable insights that can guide us towards more effective treatments and a brighter future for individuals with DS and other developmental disabilities.
Date :
  1. Date Completed 2014-01-03
  2. Date Revised 2013-05-20
Further Info :

Pubmed ID

23595836

DOI: Digital Object Identifier

10.1002/pd.4134

Related Literature

Article Analysis
・Effective treatment of prenatal testing
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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