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Cytoplasmic localization of DGKζ exerts a protective effect against p53-mediated cytotoxicity.

Author: GotoKaoru, HamamotoYoshioki, HozumiYasukazu, IinoMitsuyoshi, KitanakaChifumi, MartelliAlberto M, OkadaMasashi, TachibanaKen, TanakaToshiaki, TophamMatthew K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The p53 protein is a crucial regulator of cell function. This study investigates the role of diacylglycerol kinase ζ (DGKζ) in regulating p53 activity.
Paper Details　
Original Abstract of the Article :
The transcription factor p53 plays a crucial role in coordinating the cellular response to various stresses. Therefore, p53 protein levels and activity need to be kept under tight control. We report here that diacylglycerol kinase ζ (DGKζ) binds to p53 and modulates its function both in the cytoplas...See full text at original site
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引用元：
https://doi.org/10.1242/jcs.118711

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2014-01-16
  2. Date Revised 2013-07-02
Further Info :

Pubmed ID

23606744

DOI: Digital Object Identifier

10.1242/jcs.118711

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