Paper Details

  1. Home
  2. Paper Details

Effects of particle size, food, and capsule shell composition on the oral bioavailability of dabrafenib, a BRAF inhibitor, in patients with BRAF mutation-positive tumors.

Author: BlackmanSamuel C, CarsonStanley W, GordonMichael S, GrossmannKenneth F, InfanteJeffrey R, KnowlesLara, KracheyElizabeth C, LanKevin, LimentaniGiselle, LorussoPatricia M, NebotNoelia, OuelletDaniele, PandeGirish, SharmaSunil

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Dabrafenib is a drug being developed for melanoma. This study investigated the effect of food and drug formulation on the absorption of dabrafenib.
Paper Details　
Original Abstract of the Article :
Dabrafenib is a small-molecule inhibitor of BRAF kinase activity that is currently being developed for the treatment of BRAF V600 mutation-positive melanoma. This clinical, open-label, two-cohort (n = 14 per cohort), randomized study was designed to evaluate the effect of drug substance particle siz...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/23608920

データ提供：米国国立医学図書館（NLM）

Dabrafenib: Optimizing Delivery for Effective Treatment

Dabrafenib is a targeted therapy used to treat certain types of cancer, specifically those with a BRAF mutation. This study investigates the factors that influence the absorption and bioavailability of dabrafenib when administered orally. The researchers conducted a clinical trial, comparing the effects of different particle sizes, food intake, and capsule shell compositions on the pharmacokinetics of dabrafenib. The study found that dabrafenib bioavailability was significantly affected by these factors, highlighting the importance of optimizing drug delivery for effective treatment. This research offers valuable insights into the pharmacokinetic properties of dabrafenib, guiding the development of optimal drug formulations and administration strategies.

Dabrafenib: A Case for Personalized Drug Delivery

The study suggests that the bioavailability of dabrafenib can be significantly influenced by factors such as particle size, food intake, and capsule shell composition. This highlights the need for personalized drug delivery strategies to optimize treatment response and minimize potential variability in drug absorption.

Optimizing Treatment Efficacy: Attention to Drug Delivery

This research emphasizes the importance of considering drug delivery when developing and administering medications. By optimizing drug formulations and administration strategies, clinicians can enhance treatment efficacy and improve patient outcomes.

Dr.Camel's Conclusion

This study, like a skilled camel navigating the intricate paths of drug delivery, explores the factors that influence the bioavailability of dabrafenib. It reveals the crucial role of optimized drug delivery in achieving effective treatment response, highlighting the importance of considering drug formulation and administration strategies to maximize patient benefits.

Date :
  1. Date Completed 2014-03-05
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

23608920

DOI: Digital Object Identifier

S0022-3549(15)30921-7

Related Literature

Article Analysis
・Effects of dabrafenib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.