Study the effects of zonisamide on fine structure of rabbit basilar artery and hippocampus in rabbit subarachnoid hemorrhage model.

Author: ArikokAta Turker, BavbekMurad, BesaltiOmer, CaliskanMurat, DemirciAdnan Yalcin, SeckinHakan, YigitkanliKazim, YigitkanliTolga

Paper Details 
Original Abstract of the Article :
BACKGROUND: In this study, we investigated the effect of a novel antiepileptic drug, zonisamide (ZNS), on the basilar artery and hippocampus in a rabbit subarachnoid hemorrhage (SAH) model. METHODS: Three groups of New Zealand white rabbits were used: a sham (non-SAH) group, an SAH + saline group, ...See full text at original site
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引用元:
https://doi.org/10.1007/s00701-013-1726-9

データ提供:米国国立医学図書館(NLM)

Zonisamide: A Potential Treatment for Subarachnoid Hemorrhage

Subarachnoid hemorrhage (SAH) is a life-threatening condition that can cause significant brain damage. This study investigates the potential protective effects of zonisamide (ZNS), a novel antiepileptic drug, in a rabbit model of SAH. The researchers analyzed the impact of ZNS on the basilar artery, a major blood vessel supplying the brain, and the hippocampus, a brain region crucial for memory and learning. The findings suggest that ZNS may offer protective benefits against SAH-induced brain damage, potentially improving outcomes for patients with this condition.

Zonisamide: A Potential Protective Agent for Subarachnoid Hemorrhage

The study revealed that ZNS had a vasodilatory effect on the basilar artery, improving blood flow to the brain, and a neuroprotective effect in the hippocampus, reducing neuronal damage. These findings suggest that ZNS may have potential therapeutic applications for managing SAH, offering a glimmer of hope for improving outcomes for patients with this condition. It's like finding a hidden oasis in the desert of SAH research, offering a potential solution for protecting the brain from damage.

Living with Subarachnoid Hemorrhage: Seeking Innovative Treatments

SAH is a challenging condition, but this study offers a promising avenue for exploring new treatment options. The findings suggest that ZNS may hold potential for mitigating brain damage and improving outcomes for patients with SAH. It's like finding a hidden spring of hope in the desert of SAH treatment, offering a potential path towards a better recovery. Remember, research is crucial for developing innovative therapies and improving patient care, making this research a beacon of hope in the fight against SAH.

Dr. Camel's Conclusion

This study provides a compelling case for investigating the therapeutic potential of zonisamide in treating subarachnoid hemorrhage. It's like finding a hidden oasis in the desert of research, offering a potential solution for protecting the brain from damage. This research underscores the importance of exploring new treatment options for SAH, offering hope for a better future for patients.

Date :
  1. Date Completed 2014-03-19
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

23636337

DOI: Digital Object Identifier

10.1007/s00701-013-1726-9

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

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