Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis.

Author: BäumerWolfgang, DickhautJeannette, JaptokLukasz, KietzmannManfred, KleuserBurkhard, MischkeReinhard, SchaperKatrin

Paper Details 
Original Abstract of the Article :
It has been indicated that the sphingolipid sphingosine-1-phosphate (S1P) restrains the ability of dendritic cells to migrate to lymph nodes. Furthermore S1P has been demonstrated to inhibit cell growth in human keratinocytes. However, only little is known about the effect of S1P in hyperproliferati...See full text at original site
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引用元:
https://doi.org/10.1016/j.jdermsci.2013.03.006

データ提供:米国国立医学図書館(NLM)

S1P: A Desert Oasis in the Storm of Psoriasis

Psoriasis, a chronic skin condition, can be like a desert storm, causing itchy, scaly patches on the skin. Researchers have been exploring the role of sphingosine-1-phosphate (S1P), a naturally occurring lipid, in treating psoriasis. This study investigated the anti-proliferative and anti-inflammatory effects of S1P in mouse models of psoriasis, seeking a natural remedy to calm the storm of inflammation.

A Desert Oasis of Relief: S1P Shows Promise

The results of this study, like a shimmering oasis in the desert, suggest that S1P could potentially offer a new approach to treating psoriasis. S1P demonstrated anti-proliferative and anti-inflammatory effects in mouse models, suggesting its potential to reduce the scaling and inflammation characteristic of psoriasis. This research opens a new path for understanding the role of S1P in skin health.

Finding Calm in the Storm: Natural Solutions for Psoriasis

This study adds to the growing body of evidence suggesting the potential of natural compounds for treating psoriasis. While further research is needed to fully understand the mechanisms and safety of S1P in humans, this research provides a glimmer of hope for individuals seeking a more natural approach to managing their psoriasis. Remember, finding a path through the desert of chronic conditions requires perseverance and exploration.

Dr. Camel's Conclusion

This study provides a compelling case for the potential of S1P as a therapeutic agent for psoriasis. The anti-proliferative and anti-inflammatory effects observed in mouse models suggest a promising avenue for future research. However, further investigations are required to confirm these findings and determine the efficacy and safety of S1P in human subjects.
Date :
  1. Date Completed 2014-01-21
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

23643308

DOI: Digital Object Identifier

10.1016/j.jdermsci.2013.03.006

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PICO Info
in preparation
Languages

English

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