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Causes of death and prognostic factors in multiple endocrine neoplasia type 1: a prospective study: comparison of 106 MEN1/Zollinger-Ellison syndrome patients with 1613 literature MEN1 patients with or without pancreatic endocrine tumors.

Author: BernaMarc J, IgarashiHisato, ItoTetsuhide, JensenRobert T, UeharaHirotsugu

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.

Overview

Multiple endocrine neoplasia type 1 (MEN1) is a disorder characterized by tumors in endocrine tissues. This study analyzed the causes of death and prognostic factors in 106 MEN1 patients with pancreatic endocrine tumors and Zollinger-Ellison syndrome. The study found that two-thirds of patients died from MEN1-related causes, with malignant pancreatic endocrine tumors being the most common cause. Non-MEN1-related causes of death included cardiovascular disease, other nonendocrine tumors, and lung diseases. Poor prognostic factors included high fasting gastrin levels, presence of other functional hormonal syndromes, and liver metastases.
Paper Details　
Original Abstract of the Article :
Multiple endocrine neoplasia type 1 (MEN1) is classically characterized by the development of functional or nonfunctional hyperplasia or tumors in endocrine tissues (parathyroid, pancreas, pituitary, adrenal). Because effective treatments have been developed for the hormone excess state, which was a...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/23645327

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2013-07-09
  2. Date Revised 2022-10-05
Further Info :

Pubmed ID

23645327

DOI: Digital Object Identifier

NIHMS475074

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Languages

English

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