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Effects of estramustine and its constituents on human malignant glioma cells.

Author: HenrikssonR, LundgrenE, von SchoultzE

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Estramustine, a conjugate of estradiol-17 beta and nor-nitrogen mustard, exerted a dose-dependent antiproliferative effect on human malignant glioma cell lines, suggesting a combined mechanism of action.
Paper Details　
Original Abstract of the Article :
Estramustine, a conjugate of estradiol-17 beta and nor-nitrogen mustard currently used in prostatic cancer, was found to exert a dose-dependent antiproliferative effect on the human malignant glioma cell lines U-251 MG and U-105 MG. At equimolar concentrations the inhibitory effects of the estramust...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2369085

データ提供：米国国立医学図書館（NLM）

Estramustine: A Multifaceted Approach to Glioma Treatment

This research explores the potential of estramustine, a drug currently used to treat prostate cancer, as a treatment option for malignant glioma, a type of brain tumor. The authors investigated the antiproliferative effects of estramustine on human malignant glioma cell lines.

A Multifaceted Weapon: Estramustine's Potent Action

Their findings reveal that estramustine exerted a potent antiproliferative effect on glioma cells, surpassing the effects of its individual constituents, estradiol and nor-nitrogen mustard. This discovery, like finding a well-stocked oasis in the desert, suggests that estramustine may offer a new and effective approach to glioma treatment.

A Promise of Hope: Further Research Needed

The authors emphasize the need for further research to fully understand the mechanisms underlying estramustine's antitumor activity. This next step, like continuing a desert journey to uncover hidden treasures, will shed light on the potential of estramustine in the fight against glioma.

Dr.Camel's Conclusion

This study, like a beacon of hope illuminating the vast desert of glioma research, reveals the potential of estramustine as a new and promising treatment option. Further investigation into this drug's mechanisms of action will be crucial in unlocking its full potential for combating this challenging disease.
Date :
  1. Date Completed 1990-08-13
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2369085

DOI: Digital Object Identifier

2369085

Related Literature

Article Analysis
・Effects of estramustine
SNS
PICO Info
in preparation
Languages

English

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