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Methylnaltrexone use in a seventeen-month-old female with progressive cancer and rectal prolapse.

Author: BakerJustin N, LaubischJamie E

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A single dose of subcutaneous methylnaltrexone resolved constipation and rectal prolapse within one hour in a 17-month-old girl with progressive leukemia.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Opioid-induced constipation is commonly seen in pediatrics, especially at the end of life. As patients clinically decline, constipation often leads to increased pain and distress, while its enteral treatment becomes more challenging. METHOD: There is little information about the safety ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822361/

データ提供：米国国立医学図書館（NLM）

Methylnaltrexone: A Hope for Opioid-Induced Constipation in Pediatrics

This case report presents a compelling story of a 17-month-old girl battling leukemia and facing the debilitating challenges of opioid-induced constipation. The authors successfully treated the child's severe constipation and rectal prolapse with methylnaltrexone, a μ-opioid-receptor antagonist. This report highlights the potential of methylnaltrexone as a treatment option for opioid-induced constipation in children, especially at the end of life. The case underscores the need for further research to establish safe and effective dosing guidelines for pediatric patients.

Methylnaltrexone: A Potential Solution for Opioid-Induced Constipation in Children

This case report demonstrates the potential of methylnaltrexone in addressing opioid-induced constipation in pediatric patients, especially in cases of advanced cancer. The successful use of methylnaltrexone in this young patient provides encouraging evidence for further research and exploration of this medication's potential in pediatric care.

Opioid-Induced Constipation in Children: Navigating a Delicate Terrain

This case report sheds light on the challenges of managing opioid-induced constipation in children, a complex terrain that requires careful navigation. The report underscores the need for effective and safe treatment options for these vulnerable patients. It's like finding a safe oasis in a vast desert, offering relief and respite from the discomfort of constipation.

Dr.Camel's Conclusion

This case report provides a glimpse of hope for managing opioid-induced constipation in children, particularly in cases of advanced disease. The successful use of methylnaltrexone in this young patient highlights its potential benefits and the need for further research to establish safe and effective dosing guidelines for pediatric patients. It's a reminder that even in the harshest deserts of illness, there can be moments of respite and relief, offering hope and a chance for healing.

Date :
  1. Date Completed 2014-07-09
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23746197

DOI: Digital Object Identifier

PMC3822361

Related Literature

Article Analysis
・Side Effects of methylnaltrexone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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