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Do current incretin mimetics exploit the full therapeutic potential inherent in GLP-1 receptor stimulation?

Author: BaranovO, MeierJ J, NauckM A, RitzelR A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

GLP-1 receptor agonists are drugs used to treat type 2 diabetes. This review discusses the potential benefits and limitations of subcutaneous vs. intravenous administration of GLP-1.
Paper Details　
Original Abstract of the Article :
Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are incretin-derived glucose-lowering agents that have been used for the treatment of type 2 diabetes since 2007. Agents such as exenatide (short-acting and once weekly preparations), liraglutide, taspoglutide, albiglutide and lixisenatide lowe...See full text at original site
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引用元：
https://doi.org/10.1007/s00125-013-2953-6

データ提供：米国国立医学図書館（NLM）

The GLP-1 Revolution: A Camel's Perspective on Diabetes Treatment

In the challenging landscape of [diabetes management], we seek to develop effective and well-tolerated treatments for type 2 diabetes. This research explores the therapeutic potential of glucagon-like peptide-1 (GLP-1) receptor agonists (RAs), a class of medications that mimic the action of GLP-1, a naturally occurring hormone that regulates glucose levels. It's like finding a new oasis in the desert of diabetes treatment, offering hope for patients struggling with this chronic condition.

A Hidden Oasis in the Desert of Diabetes: A Camel's Perspective on GLP-1

The study, a journey through the desert of diabetes research, investigates the potential of GLP-1 RAs to achieve optimal glucose control while minimizing side effects. This is like searching for a hidden oasis in the desert, seeking to maximize the benefits of GLP-1 while minimizing its limitations. The study highlights the potential of GLP-1 RAs to effectively lower glucose levels, but also acknowledges the challenges of gastrointestinal side effects and the need to optimize their delivery.

Navigating the Desert of Side Effects: A Camel's Advice

This research underscores the importance of understanding the nuances of GLP-1 RAs. It's like having a map to guide us through the desert of diabetes management, helping us choose the most effective and well-tolerated treatment for each patient. The study encourages further research into optimizing the delivery and formulation of GLP-1 RAs to maximize their benefits and minimize their side effects.

Dr. Camel's Conclusion

This study offers valuable insights into the potential of GLP-1 RAs in diabetes management. It's like finding a hidden spring in the desert, providing a source of hope and potentially effective treatment. The researchers' findings suggest that GLP-1 RAs, when optimized, could offer a powerful tool for managing type 2 diabetes, but further research is needed to fully realize their potential.

Date :
  1. Date Completed 2014-05-30
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23748861

DOI: Digital Object Identifier

10.1007/s00125-013-2953-6

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Languages

English

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