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Original Abstract of the Article :
Histone deacetylase inhibitors (HDACIs) are a class of antineoplastic agent targeting the epigenome, specifically chromatin remodelling, resulting in modulation of genes responsible for apoptosis and cell cycle regulation, and also hyperacetylation of many non-histone proteins. Panobinostat is a pot...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1517/13543784.2013.815165
データ提供:米国国立医学図書館(NLM)
Panobinostat: A Powerful Tool in the Desert of Lymphoid and Myeloid Malignancies
Cancer is a relentless desert, challenging researchers to find new oases of hope. This research explores the potential of panobinostat, a histone deacetylase inhibitor (HDACI), in the fight against lymphoid and myeloid malignancies. HDACIs work by targeting the epigenome, specifically chromatin remodelling, leading to changes in gene expression related to cell death and growth. Panobinostat has shown promise in treating hematological diseases like cutaneous T-cell lymphoma, Hodgkin lymphoma, myeloma, and myeloid malignancies.
Panobinostat: A Beacon of Hope in the Desert of Hematological Malignancies
This study explores the potential of panobinostat, a potent pan-histone inhibitor of HDAC enzymes, in the treatment of lymphoid and myeloid malignancies. The authors discuss the activity of panobinostat in various hematological diseases, suggesting its potential as a new therapeutic agent for these challenging conditions.
Panobinostat: A Promise for Better Outcomes in Cancer Treatment
This research offers a glimmer of hope in the fight against cancer. Panobinostat shows promise as a new therapeutic agent for various hematological diseases, potentially leading to improved treatment outcomes for patients. This study highlights the importance of research into new treatment modalities for cancer, particularly those that target the epigenome.
Dr.Camel's Conclusion
This research provides a fascinating look into the potential of panobinostat as a new therapeutic agent for lymphoid and myeloid malignancies. The study highlights the importance of targeting the epigenome in cancer treatment and offers hope for improved treatment outcomes for patients. It's essential to continue exploring new avenues for cancer treatment, as the desert of cancer research is vast and complex.
Date :
- Date Completed 2014-03-05
- Date Revised 2018-12-02
Further Info :
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