Panobinostat in lymphoid and myeloid malignancies.

Author: DickinsonMichael, KhotAmit, PrinceH Miles

Paper Details 
Original Abstract of the Article :
Histone deacetylase inhibitors (HDACIs) are a class of antineoplastic agent targeting the epigenome, specifically chromatin remodelling, resulting in modulation of genes responsible for apoptosis and cell cycle regulation, and also hyperacetylation of many non-histone proteins. Panobinostat is a pot...See full text at original site
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引用元:
https://doi.org/10.1517/13543784.2013.815165

データ提供:米国国立医学図書館(NLM)

Panobinostat: A Powerful Tool in the Desert of Lymphoid and Myeloid Malignancies

Cancer is a relentless desert, challenging researchers to find new oases of hope. This research explores the potential of panobinostat, a histone deacetylase inhibitor (HDACI), in the fight against lymphoid and myeloid malignancies. HDACIs work by targeting the epigenome, specifically chromatin remodelling, leading to changes in gene expression related to cell death and growth. Panobinostat has shown promise in treating hematological diseases like cutaneous T-cell lymphoma, Hodgkin lymphoma, myeloma, and myeloid malignancies.

Panobinostat: A Beacon of Hope in the Desert of Hematological Malignancies

This study explores the potential of panobinostat, a potent pan-histone inhibitor of HDAC enzymes, in the treatment of lymphoid and myeloid malignancies. The authors discuss the activity of panobinostat in various hematological diseases, suggesting its potential as a new therapeutic agent for these challenging conditions.

Panobinostat: A Promise for Better Outcomes in Cancer Treatment

This research offers a glimmer of hope in the fight against cancer. Panobinostat shows promise as a new therapeutic agent for various hematological diseases, potentially leading to improved treatment outcomes for patients. This study highlights the importance of research into new treatment modalities for cancer, particularly those that target the epigenome.

Dr.Camel's Conclusion

This research provides a fascinating look into the potential of panobinostat as a new therapeutic agent for lymphoid and myeloid malignancies. The study highlights the importance of targeting the epigenome in cancer treatment and offers hope for improved treatment outcomes for patients. It's essential to continue exploring new avenues for cancer treatment, as the desert of cancer research is vast and complex.

Date :
  1. Date Completed 2014-03-05
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

23826641

DOI: Digital Object Identifier

10.1517/13543784.2013.815165

Related Literature

SNS
PICO Info
in preparation
Languages

English

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