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A pilot study of temsirolimus and body composition.

Author: JankuFilip, KurzrockRazelle, NaingAung, ParsonsHenrique A, TsimberidouApostolia M, Veasey-RodriguesHeloisa, WhelerJennifer J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Temsirolimus, an mTOR inhibitor, was associated with weight loss in patients with advanced solid tumors. Patients with higher grade toxicities tended to lose more body fat, suggesting a possible end-organ metabolic effect of temsirolimus.
Paper Details　
Original Abstract of the Article :
PURPOSE: Body weight and composition play a role in cancer etiology, prognosis, and treatment response. Therefore, we analyzed the weight, body composition changes, and outcome in patients treated with temsirolimus, an mTor inhibitor that has weight loss as one of its side effects. PATIENTS AND MET...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830004/

データ提供：米国国立医学図書館（NLM）

Temsirolimus and Body Composition Changes

The landscape of cancer treatment is vast and constantly evolving. This study explores the impact of temsirolimus, an mTOR inhibitor, on body composition in patients with advanced solid tumors. The authors investigated the potential effects of temsirolimus on body weight and composition, much like a camel navigating a shifting desert landscape, adapting to the changing terrain.

Temsirolimus's Impact on Body Composition

The researchers found that temsirolimus was associated with weight loss, particularly in patients experiencing higher grades of toxicity. These findings suggest that temsirolimus may have a metabolic effect on the body, impacting both muscle and fat mass. This is like a camel adapting to the changing environment, adjusting its body composition to conserve resources and navigate a challenging terrain.

Potential Implications for Cancer Treatment

This study's findings highlight the importance of monitoring body composition in patients receiving temsirolimus. Understanding the potential metabolic effects of temsirolimus may lead to better strategies for managing side effects and optimizing treatment outcomes. This is like understanding the unique characteristics of a desert ecosystem, allowing for a more targeted and effective approach to conservation and management.

Dr. Camel's Conclusion

This study provides valuable insights into the impact of temsirolimus on body composition. The findings suggest that temsirolimus may have significant metabolic effects, highlighting the importance of careful monitoring and personalized management strategies. This research contributes to the ongoing quest for more effective and less toxic cancer treatments, a journey through a vast and complex desert of scientific discovery.
Date :
  1. Date Completed 2013-11-18
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23893509

DOI: Digital Object Identifier

PMC3830004

Related Literature

Article Analysis
・Side Effects of temsirolimus
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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