Cabozantinib (XL184) for the treatment of locally advanced or metastatic progressive medullary thyroid cancer.

Author: CappagliVirginia, EliseiRossella, ViolaDavid

Paper Details 
Original Abstract of the Article :
Cabozantinib (XL184) is an oral multiple receptor tyrosine kinase inhibitor manufactured by Exelixis Inc., CA, USA. It mainly inhibits three tyrosine kinase receptors: MET, VEGFR2 and RET. In both preclinical and clinical studies it has been shown to inhibit tumor angiogenesis, invasiveness and meta...See full text at original site
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引用元:
https://doi.org/10.2217/fon.13.128

データ提供:米国国立医学図書館(NLM)

Cabozantinib: A Promising Treatment for Medullary Thyroid Cancer

This study explores the potential of cabozantinib (XL184), an oral multiple receptor tyrosine kinase inhibitor, in treating locally advanced or metastatic progressive medullary thyroid cancer (MTC). The researchers, akin to explorers venturing into a challenging desert terrain, investigated the efficacy of cabozantinib in a Phase III clinical trial (EXAM study). The study found that cabozantinib significantly improved overall response rates and progression-free survival in patients with advanced MTC compared to placebo. The drug has been approved by the US FDA for the treatment of advanced MTC, offering a promising treatment option for patients with this challenging condition.

Cabozantinib: A Beacon of Hope for Medullary Thyroid Cancer Patients

The study's findings demonstrate the significant potential of cabozantinib in treating advanced MTC, offering a promising treatment option for patients with this complex and often aggressive condition. The observed improvements in overall response rates and progression-free survival compared to placebo highlight the drug's efficacy in managing MTC, potentially leading to improved quality of life and extended survival for patients.

Navigating the Desert of Thyroid Cancer: Finding Relief with Cabozantinib

Thyroid cancer, like a hidden oasis in a vast desert, can be a challenging condition to diagnose and manage. This study offers a glimmer of hope for patients with MTC, highlighting the potential of cabozantinib as a valuable treatment option. The findings suggest that cabozantinib can significantly improve outcomes for patients with advanced MTC, potentially leading to extended survival and improved quality of life. As researchers continue to explore the complexities of thyroid cancer, they are paving the way for more effective treatments and improved outcomes for those affected by this condition.

Dr.Camel's Conclusion

This research provides compelling evidence for the efficacy of cabozantinib in treating advanced MTC, offering a significant advancement in the management of this challenging condition. The study's findings highlight the importance of ongoing research and the development of new treatments for complex diseases like MTC, enabling those affected to navigate the journey of their condition with greater hope and resilience.

Date :
  1. Date Completed 2013-11-01
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

23902240

DOI: Digital Object Identifier

10.2217/fon.13.128

Related Literature

SNS
PICO Info
in preparation
Languages

English

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