Paper Details

  1. Home
  2. Paper Details

The effect of modafinil on fatigue, cognitive functioning, and mood in primary brain tumor patients: a multicenter randomized controlled trial.

Author: BoeleFlorien W, CleijneWilmy, DouwLinda, HeimansJan J, KleinMartin, ReijneveldJaap C, TaphoornMartin J B, de GrootMarjolein, van ThuijlHinke F

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Modafinil effectively improved fatigue, depression, and cognitive functioning in patients with primary brain tumors (PBTs).
Paper Details　
Original Abstract of the Article :
Fatigue, cognitive deficits, and depression are frequently reported but often undertreated symptoms that can profoundly affect daily life in patients with primary brain tumors (PBTs). To evaluate the effects of the psychostimulant modafinil on fatigue, depression, health-related quality of life (HRQ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779045/

データ提供：米国国立医学図書館（NLM）

Modafinil: A Potential Remedy for Fatigue and Cognitive Deficits in Brain Tumor Patients

Fatigue, cognitive deficits, and depression are common yet frequently undertreated symptoms for patients diagnosed with primary brain tumors (PBTs). This research investigated the potential of modafinil, a psychostimulant, to alleviate these debilitating symptoms and improve quality of life in PBT patients. The study involved a multicenter, double-blind placebo-controlled crossover trial to assess the effects of modafinil on fatigue, depression, health-related quality of life (HRQOL), and cognitive functioning.

Modafinil's Impact on Fatigue and Cognitive Function

The results of this study provide promising insights into the potential benefits of modafinil for PBT patients. While further investigation is needed, the study suggests that modafinil may effectively mitigate fatigue and cognitive deficits, potentially leading to improved quality of life for these individuals. This finding offers a glimmer of hope for patients facing these challenges, suggesting a potential pathway for improved management of their symptoms.

Improved Quality of Life for Brain Tumor Patients

By targeting fatigue and cognitive deficits, modafinil may help improve overall well-being and quality of life for PBT patients. This could translate into greater independence, increased participation in daily activities, and an enhanced sense of overall health. Just as a camel navigates the unforgiving desert, PBT patients often need support to cope with the physical and mental challenges they face. Modafinil may provide a valuable tool in their journey.

Dr.Camel's Conclusion

This research explores a potential avenue for improving the lives of PBT patients by addressing the debilitating symptoms of fatigue and cognitive deficits. While further investigation is needed, modafinil's potential to alleviate these symptoms offers hope for a better quality of life. Like a camel's resilience in the desert, PBT patients demonstrate incredible strength in their fight against this challenging illness.

Date :
  1. Date Completed 2014-05-02
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

23925452

DOI: Digital Object Identifier

PMC3779045

Related Literature

Article Analysis
・Side Effects of modafinil
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.