Paper Details

  1. Home
  2. Paper Details

Safety and immunogenicity of 13-valent pneumococcal conjugate vaccine in infants: a meta-analysis.

Author: Grande-TejadaA M, Molina-LindeJ M, Márquez PeláezS, Ruiz-AragónJ

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

The 13-valent pneumococcal conjugate vaccine demonstrated similar safety and efficacy to the 7-valent vaccine, providing expanded protection against six additional serotypes. The vaccine was well tolerated and showed high immunogenicity for all tested serotypes, making it a valuable tool for preventing invasive pneumococcal disease in infants.
Paper Details　
Original Abstract of the Article :
Pneumococcal infections are a major cause of morbidity and mortality worldwide. Pneumococcal conjugate vaccines represent major progress in the prevention of invasive pneumococcal disease in the paediatric population. We performed a meta-analysis, in accordance with the PRISMA statement, in order to...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.vaccine.2013.09.008

データ提供：米国国立医学図書館（NLM）

A Meta-Analysis: Comparing the Safety and Immunogenicity of Pneumococcal Conjugate Vaccines

Pneumococcal infections, like a sandstorm sweeping through a desert, pose a significant threat to children's health. Pneumococcal conjugate vaccines, however, offer a powerful shield against these infections.

This meta-analysis, a comprehensive review of multiple studies, aimed to assess the immunogenicity and safety of 13-valent pneumococcal conjugate vaccines in infants, comparing them to the widely used 7-valent vaccine.

A Promising Shield Against Pneumococcal Infections

The researchers analyzed data from nine randomized clinical trials, finding that both vaccines were well tolerated. Importantly, both the 7-valent and 13-valent vaccines demonstrated high immunogenicity against the serotypes they targeted, effectively stimulating the immune system to mount a defense against these potentially harmful bacteria.

Expanded Protection for Infants

The meta-analysis showed that the 13-valent vaccine provided comparable safety to the 7-valent vaccine while offering expanded protection against six additional serotypes. This finding highlights the potential of the 13-valent vaccine to further strengthen the defenses against pneumococcal infections in infants.

Dr. Camel's Conclusion

This meta-analysis is a testament to the power of scientific collaboration. By pooling data from multiple studies, researchers have provided compelling evidence that the 13-valent pneumococcal conjugate vaccine offers a safe and effective shield against pneumococcal infections, potentially improving the health and well-being of infants worldwide.

Date :
  1. Date Completed 2014-06-02
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

24055349

DOI: Digital Object Identifier

10.1016/j.vaccine.2013.09.008

Related Literature

Article Analysis
・Side Effects of pneumococcal conjugate vaccine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.