In vitro activity of Ozenoxacin against quinolone-susceptible and quinolone-resistant gram-positive bacteria.

Author: CantónR, EspinalP, Garcia-AlonsoF, Gargallo-ViolaD, LópezY, TatoM, VilaJ

Paper Details 
Original Abstract of the Article :
In vitro activity of ozenoxacin, a novel nonfluorinated topical (L. D. Saravolatz and J. Leggett, Clin. Infect. Dis. 37:1210-1215, 2003) quinolone, was compared with the activities of other quinolones against well-characterized quinolone-susceptible and quinolone-resistant Gram-positive bacteria. Oz...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837899/

データ提供:米国国立医学図書館(NLM)

Ozenoxacin: A Novel Quinolone for Topical Treatment of Gram-Positive Infections

This research focuses on the development of new antibacterial agents, specifically exploring the potential of ozenoxacin, a non-fluorinated quinolone, in treating gram-positive bacterial infections. The study compared the in vitro activity of ozenoxacin with other quinolones against both susceptible and resistant strains of gram-positive bacteria. The results demonstrated that ozenoxacin exhibited significantly greater activity against these bacteria compared to other quinolones, suggesting its potential as a first-in-class non-fluorinated quinolone for topical treatment of dermatological infections.

Ozenoxacin Shows Promise as a New Topical Antibacterial Agent

The study highlights the exceptional activity of ozenoxacin against both susceptible and resistant strains of gram-positive bacteria, particularly in comparison to other quinolones. Its promising results suggest that ozenoxacin could be a valuable addition to the arsenal of topical antibacterial agents, particularly for the treatment of skin infections.

The Health Implications and Practical Applications

The development of new antibacterial agents is crucial in the fight against antibiotic resistance. Ozenoxacin's potent activity against gram-positive bacteria, particularly those resistant to other antibiotics, suggests its potential to address this growing public health concern. Its topical application makes it a promising candidate for treating a range of skin infections.

Dr.Camel's Conclusion

This research, like a desert traveler discovering a hidden spring of fresh water, unveils the potential of ozenoxacin as a novel antibacterial agent. Its potent activity against gram-positive bacteria, especially resistant strains, offers a promising solution to the challenge of antibiotic resistance.

Date :
  1. Date Completed 2014-06-19
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24080666

DOI: Digital Object Identifier

PMC3837899

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English

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