Protective effects of zonisamide against rotenone-induced neurotoxicity.

Author: CaccamoDaniela, CalabresiPaolo, CondelloSalvatore, CostaCinzia, CostaGregorio, CurròMonica, FerlazzoNadia, IentileRiccardo, PisaniFrancesco, PisaniLaura Rosa, VisalliGiuseppa

Paper Details 
Original Abstract of the Article :
Zonisamide (ZNS), an antiepileptic drug having beneficial effects also against Parkinson's disease symptoms, has proven to display an antioxidant effects in different experimental models. In the present study, the effects of ZNS on rotenone-induced cell injury were investigated in human neuroblastom...See full text at original site
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引用元:
https://doi.org/10.1007/s11064-013-1181-2

データ提供:米国国立医学図書館(NLM)

Zonisamide: A Potential Protector Against Neuronal Damage

Neurodegenerative diseases, like a relentless desert storm, pose a significant threat to brain health. This research, like a dedicated neuroscientist seeking ways to combat neuronal damage, investigates the neuroprotective effects of zonisamide, an antiepileptic drug, against rotenone-induced neurotoxicity. The researchers used human neuroblastoma cells to model neuronal damage and explore the potential of zonisamide to mitigate the harmful effects of rotenone, a toxin known to damage neurons.

A Protective Shield Against Neuronal Damage: A Ray of Hope

The study's findings suggest that zonisamide may offer protection against neuronal damage. The researchers observed that zonisamide effectively reduced rotenone-induced cell death, preventing the toxin from wreaking havoc on neurons. Zonisamide, like a sturdy shield in the desert, appears to protect neurons from damage, potentially offering a glimmer of hope for those struggling with neurodegenerative diseases.

Protecting Brain Health: A Path to a Brighter Future

This research sheds light on the potential of zonisamide as a neuroprotective agent, offering hope for the development of new therapies for neurodegenerative diseases. The researchers' findings, like a map guiding researchers through the vast desert of neurodegenerative research, suggest a promising avenue for further exploration and development of therapies to protect neurons and preserve brain function.

Dr. Camel's Conclusion

This research highlights the potential of zonisamide to protect neurons from damage, providing a promising lead for the development of new therapies for neurodegenerative diseases. The researchers' findings, like a beacon of hope shining in the desert, offer a glimpse of a future where we can better combat the devastating effects of these diseases.
Date :
  1. Date Completed 2014-07-21
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24142350

DOI: Digital Object Identifier

10.1007/s11064-013-1181-2

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SNS
PICO Info
in preparation
Languages

English

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