Drug discovery and human African trypanosomiasis: a disease less neglected?

Author: BaellJonathan B, FerrinsLori, RahmaniRaphaël

Paper Details 
Original Abstract of the Article :
Human African trypanosomiasis (HAT) has been neglected for a long time. The most recent drug to treat this disease, eflornithine, was approved by the US FDA in 2000. Current treatments exhibit numerous problematic side effects and are often ineffective against the debilitating CNS resident stage of ...See full text at original site
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引用元:
https://doi.org/10.4155/fmc.13.162

データ提供:米国国立医学図書館(NLM)

Human African Trypanosomiasis: A Neglected Disease?

Dr. Camel here, and I'm here to shed light on a crucial challenge in the field of [drug discovery] – Human African Trypanosomiasis (HAT). HAT has been a neglected disease for a long time, much like a lost oasis in the vast desert of medical research. The last drug approved for treating this debilitating disease, eflornithine, was introduced by the US FDA in 2000. Existing treatments often fall short, riddled with troublesome side effects, and failing to combat the debilitating CNS stage of the disease. Thankfully, a resurgence of partnerships and initiatives has emerged over the past two decades. These efforts, aimed at eradicating HAT and other neglected diseases, have spurred the growth of research institutions and foundations dedicated to developing new drugs, diagnostic tools, and treatment methods. The emergence of new biochemical pathways as potential therapeutic targets has been accompanied by a surge in new antitrypanosomal compound classes. The future, my friends, appears promising as this collaborative approach holds the key to unlocking long-awaited breakthroughs in treating HAT.

A Collaborative Approach to Fight HAT

This collaborative research is crucial for addressing a critical issue in [global health] – neglected diseases like HAT. The recent surge in research and partnerships is a ray of hope in the vast desert of neglected diseases. The numbers are promising – an increasing number of foundations and research institutions are tackling this challenge. The focus on new biochemical pathways and antitrypanosomal compounds showcases a dynamic and promising approach. It's like discovering a new spring of fresh water in the heart of the desert.

A Promise of Hope

This research offers hope for a better future for those suffering from HAT. These breakthroughs in the treatment of HAT can lead to a healthier and more fulfilling life for affected individuals, much like a blooming flower in the barren desert.

Dr. Camel's Conclusion

This collaborative research offers hope for the future of HAT treatment. The emergence of new drug candidates, diagnostic tools, and treatment methods is a testament to the power of research and collaboration. It's a reminder that even in the vast desert of neglected diseases, we can find oases of hope.

Date :
  1. Date Completed 2014-05-16
  2. Date Revised 2013-10-22
Further Info :

Pubmed ID

24144414

DOI: Digital Object Identifier

10.4155/fmc.13.162

Related Literature

SNS
PICO Info
in preparation
Languages

English

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