Paper Details

  1. Home
  2. Paper Details

Nephroprotective effects of TVP1022, a non-MAO inhibitor S-isomer of rasagiline, in an experimental model of diabetic renal ischemic injury.

Author: AbassiZaid, Abu-SalehNiroz, ArmalyZaher, AwadHoda, HeymanSamuel N, HolmanJames, IchimuraTakaharu, KaballaAviva, KarramTony, KhamaisiMogher

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the protective effects of TVP1022 and tempol on ischemic acute kidney injury (iAKI) in diabetic rats.
Paper Details　
Original Abstract of the Article :
Ischemic acute kidney injury (iAKI) in diabetes mellitus is associated with a rapid deterioration of kidney function, more than in nondiabetic subjects. TVP1022, a non-MAO inhibitor S-isomer of rasagiline, possesses antioxidative and antiapoptotic activities. The current study examines the effects o...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1152/ajprenal.00379.2013

データ提供：米国国立医学図書館（NLM）

TVP1022: A Potential Oasis in the Desert of Diabetic Kidney Injury

Diabetic kidney injury (AKI) is a challenging condition that often leads to a rapid deterioration of kidney function. This research explores the potential of TVP1022, a non-MAO inhibitor, to protect against AKI in diabetic rats. The researchers examined the effects of TVP1022 on renal function and histological changes in a model of ischemic AKI in diabetic rats.

The researchers found that TVP1022 treatment significantly improved renal function and reduced histological damage in diabetic rats with AKI. They observed a significant increase in glomerular filtration rate (GFR) and a reduction in renal necrosis and inflammation. This suggests that TVP1022 may have a protective effect on the kidneys in diabetic patients with AKI.

A Beacon of Hope in the Desert of Diabetic Kidney Disease

This research offers a glimmer of hope in the challenging landscape of diabetic kidney disease. The findings suggest that TVP1022 may offer a potential treatment for AKI in diabetic patients. This could have a significant impact on the health and well-being of individuals living with diabetes and kidney disease.

Navigating the Desert of Diabetic Kidney Disease

The desert of diabetic kidney disease can be a difficult and daunting one, but this research provides a valuable insight into the potential of TVP1022 to improve outcomes for these patients. The findings suggest that this compound may offer a new and potentially effective treatment option, providing a beacon of hope for individuals struggling with this challenging condition.

Dr.Camel's Conclusion

This research is like finding a hidden oasis in the vast desert of diabetic kidney disease. TVP1022 offers a potential solution to protect against AKI, providing a ray of hope for individuals living with this challenging condition. This finding suggests that TVP1022 may offer a valuable new tool in our fight against diabetic kidney disease.

Date :
  1. Date Completed 2014-02-28
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

24197064

DOI: Digital Object Identifier

10.1152/ajprenal.00379.2013

Related Literature

Article Analysis
・Effects of rasagiline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.