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Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations.

Author: BerglundEva Gil, GiacominiKathleen M, HsuVicky, HuangShiew-Mei, NordmarkAnna, ZhangLei, ZhaoPing, ZhengJenny Huimin, de L T VieiraManuela

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

The kidney plays a significant role in drug elimination. Renal impairment or the use of transporter inhibitors can decrease active secretion and increase exposure to drugs that are substrates of kidney secretory transporters. This study utilized physiologically based pharmacokinetic (PBPK) modeling to evaluate the effects of patient factors on kidney transporters.
Paper Details　
Original Abstract of the Article :
The kidney is a major drug-eliminating organ. Renal impairment or concomitant use of transporter inhibitors may decrease active secretion and increase exposure to a drug that is a substrate of kidney secretory transporters. However, prediction of the effects of patient factors on kidney transporters...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927056/

データ提供：米国国立医学図書館（NLM）

Unraveling the Complexities of Kidney Transport: A Modeling Approach

The realm of drug development is intricately intertwined with the understanding of how our bodies process and eliminate medications. This study dives into the complexities of renal drug transport, specifically focusing on the impact of kidney impairment and transporter inhibitors on drug efficacy.

Predicting Drug Behavior: A Modeling Approach to Kidney Transport

The authors utilize a physiologically based pharmacokinetic (PBPK) modeling approach to simulate and predict the effects of patient factors on kidney transporters. This innovative approach offers a powerful tool for understanding and predicting drug behavior in individuals with varying kidney function and potential drug interactions.

Optimizing Drug Therapy: A Key Role for PBPK Modeling

This study highlights the importance of PBPK modeling in optimizing drug therapy. By providing a deeper understanding of drug transport processes, PBPK modeling can help predict drug exposure and optimize treatment regimens, ultimately leading to improved patient outcomes.

Dr. Camel's Conclusion

This research takes us on a journey through the complex world of renal drug transport, showcasing the power of PBPK modeling in predicting drug behavior. The authors' innovative approach offers valuable insights for optimizing drug therapy and ensuring the safe and effective use of medications.

Date :
  1. Date Completed 2014-12-08
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24214317

DOI: Digital Object Identifier

PMC3927056

Related Literature

Article Analysis
・Effects of probenecid
SNS
PICO Info
in preparation
Languages

English

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