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Efficacy and safety of collagenase Clostridium histolyticum injection for Dupuytren contracture: report of 40 cases.

Author: AdaniR, AlbertonF, CorainM, GarofanoA, PangalloL, ValoreA, ZanellaV

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

Dupuytren's disease (DD) is a fibroproliferative pathology that affects the palmar aponeurosis, causing nodules and collagen cords and progressive finger flexion. Surgical fasciectomy is the standard treatment, but recurrence rates are high. Collagenase Clostridium histolyticum (CCH) injection offers a noninvasive alternative. This prospective study examined the efficacy and safety of outpatient CCH injections using local anesthesia.
Paper Details　
Original Abstract of the Article :
Dupuytren's disease (DD) is a fibroproliferative pathology that affects the palmar aponeurosis causing the development of nodules and collagen cords and the progressive flexion of the fingers. The standard procedure is surgical fasciectomy, followed by high recurrence rates. Collagenase Clostridium ...See full text at original site
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引用元：
https://doi.org/10.1007/s12306-013-0304-x

データ提供：米国国立医学図書館（NLM）

Investigating Collagenase Clostridium Histolyticum Injection for Dupuytren Contracture

Dupuytren's disease (DD) is a condition that affects the hand, causing the fingers to bend inward, often limiting mobility and functionality. Traditional treatment for DD has been surgical fasciectomy, but this procedure can be associated with complications and a high recurrence rate. This research explores the effectiveness and safety of a non-invasive treatment option for DD: injection of collagenase Clostridium histolyticum (CCH).

The study, involving 40 patients with DD, evaluated the efficacy and safety of CCH injections performed in an outpatient setting. The researchers found that CCH injections were effective in improving finger extension and reducing the severity of DD. The procedure was also well-tolerated, with minimal side effects and complications. The study concluded that CCH injections represent a promising non-invasive alternative to surgical fasciectomy for treating DD.

Non-Invasive Treatment Options for Dupuytren's Disease

This research provides compelling evidence for the effectiveness and safety of CCH injections in treating DD. The study's findings offer a less invasive and potentially more convenient alternative to surgical intervention. This could benefit patients seeking to avoid the risks and recovery time associated with surgery.

Improving Treatment Options for Dupuytren's Disease

The exploration of non-invasive treatments like CCH injections is a positive development in the management of DD. This research, like a refreshing oasis in the desert of hand-related conditions, offers a new avenue for treating this debilitating disease, potentially improving quality of life for individuals affected by DD.

Dr.Camel's Conclusion

Navigating the challenges of Dupuytren's disease can feel like traversing a treacherous desert landscape. This research, like a well-stocked caravan, provides hope for those seeking a less invasive treatment option. The findings suggest that CCH injections offer a potential path towards regaining hand functionality and improving quality of life.

Date :
  1. Date Completed 2017-08-10
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24254968

DOI: Digital Object Identifier

10.1007/s12306-013-0304-x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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