Cytoprotective Effects of Organosulfur Compounds against Methimazole Induced Toxicity in Isolated Rat Hepatocytes.

Author: BabaeiHossein, EghbalMohammad Ali, HeidariReza

Paper Details 
Original Abstract of the Article :
Methimazole is a drug widely used in hyperthyroidism. However, life threatening hepatotoxicity has been associated with its clinical use. No protective agent has been found to be effective against methimazole induced hepatotoxicity yet. Hence, the capacity of organosulfur compounds to protect rat he...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846059/

データ提供:米国国立医学図書館(NLM)

Protecting the Liver: Exploring Organosulfur Compounds' Potential Against Methimazole Toxicity

This study explores the potential protective effects of organosulfur compounds against methimazole-induced toxicity in isolated rat hepatocytes. Methimazole, a commonly used medication for hyperthyroidism, can cause life-threatening hepatotoxicity, highlighting the need for effective protective agents. The study evaluated the ability of organosulfur compounds to mitigate the cytotoxic effects of methimazole and its proposed toxic metabolite, N-methylthiourea. The findings provide promising evidence for the potential of these compounds to protect the liver from methimazole-induced damage.

Organosulfur Compounds: A Potential Shield Against Methimazole Toxicity

This study demonstrates the potential of organosulfur compounds as protective agents against methimazole-induced hepatotoxicity. The findings suggest that these compounds may offer a promising therapeutic strategy for preventing liver damage associated with this commonly used medication. Further research is needed to evaluate the efficacy and safety of organosulfur compounds in clinical settings.

Implications for Liver Health

Dr. Camel advises that understanding the mechanisms underlying methimazole-induced hepatotoxicity and exploring potential protective agents is crucial for maintaining liver health. This research offers valuable insights into the potential of organosulfur compounds to safeguard the liver from methimazole-induced damage. Continued research in this area could lead to the development of more effective and targeted therapies for preventing and managing liver toxicity associated with methimazole and other medications.

Dr. Camel's Conclusion

Just as a camel stores precious water in its hump to survive the arid desert, our liver plays a vital role in maintaining our overall health. This research sheds light on the potential of organosulfur compounds to protect the liver from the harmful effects of methimazole, a commonly used medication. By exploring these natural compounds, we may one day find new ways to safeguard this vital organ and improve health outcomes for individuals receiving methimazole therapy.

Date :
  1. Date Completed 2013-12-06
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24312826

DOI: Digital Object Identifier

PMC3846059

Related Literature

SNS
PICO Info
in preparation
Languages

English

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