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Evaluation of the effect of UGT1A1 polymorphisms on dolutegravir pharmacokinetics.

Author: BorlandJulie, ChenShuguang, PiscitelliStephen, RubioJustin P, SongIvy, St JeanPamela, YeoAstrid J

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Carriers of UGT1A1 reduced function polymorphisms did not experience clinically significant increases in dolutegravir exposure, so dose adjustment is not required.
Paper Details　
Original Abstract of the Article :
AIM: To evaluate potential pharmacogenetic effects of UGT1A1 polymorphisms on the pharmacokinetics (PK) of dolutegravir (Tivicay®; ViiV Healthcare, NC, USA), an HIV-1 integrase inhibitor. PATIENTS & METHODS: Analysis of pooled data from nine Phase I and II clinical studies was undertaken for 89 sub...See full text at original site
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引用元：
https://doi.org/10.2217/pgs.13.190

データ提供：米国国立医学図書館（NLM）

UGT1A1 Polymorphisms and Dolutegravir Pharmacokinetics

This fascinating study delves into the complex world of pharmacogenetics, exploring how individual genetic variations can influence drug metabolism and, consequently, affect treatment outcomes. The research focuses on dolutegravir, an HIV-1 integrase inhibitor, and its interaction with UGT1A1 polymorphisms, variations in a specific gene involved in drug metabolism. The authors meticulously analyzed data from nine clinical studies to unravel the potential pharmacogenetic effects of UGT1A1 polymorphisms on dolutegravir pharmacokinetics.

Individualized Dolutegravir Therapy

The research reveals that individuals carrying certain UGT1A1 polymorphisms exhibit altered dolutegravir pharmacokinetics, resulting in increased drug exposure. However, the study reassuringly concludes that these alterations in drug exposure are not clinically significant based on accumulated safety data. Therefore, dose adjustments for individuals with these polymorphisms are not required, ensuring safe and effective treatment with dolutegravir.

Tailoring Treatment for Optimal Results

This research underscores the growing importance of understanding individual genetic variations to tailor treatment strategies for optimal outcomes. The study emphasizes that the influence of UGT1A1 polymorphisms on dolutegravir pharmacokinetics, although noticeable, does not necessitate dosage adjustments. It's like having a map of the desert, allowing us to navigate the unique metabolic pathways of individuals to ensure safe and effective treatment with dolutegravir.

Dr.Camel's Conclusion

This research offers valuable insights into the interplay between genetics and drug metabolism. The study demonstrates the significance of individual genetic variations in influencing drug pharmacokinetics, highlighting the importance of pharmacogenetic considerations in tailoring treatment strategies for optimal outcomes. It's like uncovering hidden pathways in the vast desert of human genetics, leading to more personalized and effective treatment approaches.

Date :
  1. Date Completed 2014-07-07
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

24329186

DOI: Digital Object Identifier

10.2217/pgs.13.190

SNS
PICO Info
in preparation
Languages

English

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