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Effects of midodrine on experimentally-induced postural hypotension in dogs.

Author: AiharaH, KanekoK, TsuchidaK, YamazakiR

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Midodrine was found to be effective in attenuating the decrease in blood pressure, cerebral tissue blood flow, vertebral arterial blood flow, and cardiac output induced by experimental postural hypotension in anesthetized dogs. The drug appears to be useful in treating postural hypotension by vasoconstriction.
Paper Details　
Original Abstract of the Article :
Effects of alpha-(2,5-dimethoxyphenyl)-beta-glycinamide-ethanol hydrochloride (midodrine, ST-1085) on experimental postural hypotension was examined in hexamethonium (20 mg/kg s.c.)-treated anesthetized dogs. The dogs were tilted 30 degrees to a head-up position. A 30 degree-tilt caused a significan...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2436631

データ提供：米国国立医学図書館（NLM）

Midodrine: A Potential Solution for Postural Hypotension

This study explores the field of cardiovascular pharmacology, focusing on the drug midodrine (ST-1085) and its effectiveness in treating postural hypotension, a condition where blood pressure drops significantly when standing up. Researchers investigated the effects of midodrine on dogs with experimentally induced postural hypotension using hexamethonium, a drug that causes a decrease in blood pressure. The study used a controlled experimental design to measure changes in blood pressure, heart rate, and blood flow in different areas of the body.

Midodrine Effectively Combats Postural Hypotension

The researchers found that midodrine significantly attenuated the decrease in blood pressure, cerebral tissue blood flow, vertebral arterial blood flow, and cardiac output induced by postural hypotension. The effects were observed at 10 and 30 minutes after administering the drug. Midodrine also showed a tendency to reduce the decrease in femoral arterial blood flow. The researchers concluded that midodrine, via vasoconstriction, appears to be useful for treating the decreased blood flow associated with postural hypotension.

Navigating Postural Hypotension

This research sheds light on a potential solution for individuals experiencing postural hypotension. Understanding how midodrine works can help in managing the condition. It's important to note that this study was conducted on dogs, so further research is needed to confirm the effectiveness and safety of midodrine in humans. If you suspect you have postural hypotension, consult with a healthcare professional for appropriate diagnosis and treatment.

Dr.Camel's Conclusion

Like a camel adapting to the changing landscape of the desert, our bodies sometimes struggle with sudden shifts in blood pressure. This study provides valuable insights into how midodrine might help combat postural hypotension, offering hope for individuals experiencing this condition.

Date :
  1. Date Completed 1987-04-29
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2436631

DOI: Digital Object Identifier

2436631

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Languages

English

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