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Haloperidol-induced changes in neuronal activity in the striatum of the freely moving rat.

Author: Bar-GadIzhar, CohenDana, KatzDonald B, MoranAnan, SandDaniel, TemelYasin, YaelDorin, ZeefDagmar H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Haloperidol, a dopamine D2 antagonist, was found to decrease the firing rate of fast spiking interneurons (FSIs) and medium spiny neurons (MSNs) in the rat striatum. It also increased the tendency of these neurons to fire in an oscillatory manner. Haloperidol increased the firing rate of tonically active neurons (TANs) but did not affect their non-oscillatory firing pattern.
Paper Details　
Original Abstract of the Article :
The striatum is the main input structure of the basal ganglia, integrating input from the cerebral cortex and the thalamus, which is modulated by midbrain dopaminergic input. Dopamine modulators, including agonists and antagonists, are widely used to relieve motor and psychiatric symptoms in a varie...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864134/

データ提供：米国国立医学図書館（NLM）

Haloperidol-Induced Changes in Neuronal Activity in the Striatum of the Freely Moving Rat

The striatum, a key component of the basal ganglia, is like a busy desert marketplace where information is exchanged. This study, like a curious desert explorer investigating the intricate workings of the brain, examines the effects of haloperidol, a dopamine D2 antagonist, on the activity of different neuronal populations in the striatum of freely moving rats.

Haloperidol's Impact on Neuronal Activity

The researchers found that haloperidol decreased the firing rate of medium spiny neurons (MSNs) and fast spiking interneurons (FSIs), while increasing their tendency to fire in an oscillatory manner. Haloperidol also increased the firing rate of tonically active neurons (TANs). These findings suggest that dopamine plays a crucial role in regulating striatal activity.

Understanding Brain Function

This study contributes to our understanding of the complex interplay between dopamine and neuronal activity in the striatum. It provides insights into the mechanisms by which haloperidol exerts its effects and helps us understand the role of the striatum in various neurological and psychiatric conditions.

Dr.Camel's Conclusion

Just as a camel can navigate a complex desert landscape, our brains rely on the intricate communication between different neuronal populations. This study delves into the effects of haloperidol on the striatum, helping us better understand the neural mechanisms underlying a variety of neurological and psychiatric conditions.

Date :
  1. Date Completed 2013-12-31
  2. Date Revised 2022-03-09
Further Info :

Pubmed ID

24379762

DOI: Digital Object Identifier

PMC3864134

Related Literature

Article Analysis
・Effects of haloperidol injection
SNS
PICO Info
in preparation
Languages

English

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