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Effects of vitamin b6 therapy for sepsis patients with linezolid-associated cytopenias: a retrospective study.

Author: DengJie, FengDan, JiaYan-Hong, LiangLi-Ling, LiangZhi-Xin, SuLong-Xiang, XieLi-Xin, YanPeng, ZhangXin-Gang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Septic patients who received a combination treatment of linezolid and vitamin B6 experienced fewer linezolid-associated reductions in red blood cell count, hemoglobin, and hematocrit. This combination also appeared to slow platelet reduction.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The common adverse effects of linezolid for treating septic patients with gram-positive cocci is anemia and thrombocytopenia, which limit its clinical application. OBJECTIVES: We determined the effects of vitamin B6 adjunctive therapy on linezolid-associated cytopenias, and retrospectiv...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862191/

データ提供：米国国立医学図書館（NLM）

Linezolid-Associated Cytopenias: Navigating the Desert of Side Effects

Linezolid, a powerful antibiotic used to treat infections caused by gram-positive bacteria, can sometimes cause side effects such as anemia and thrombocytopenia. This study investigates the potential of vitamin B6 as an adjunctive therapy to mitigate these side effects. The researchers, like explorers seeking a way to minimize the impact of adverse events in the desert of antibiotic treatment, conducted a retrospective study involving 75 septic patients receiving linezolid treatment.

Vitamin B6: A Potential Oasis in the Desert of Side Effects

The study's findings provide a glimmer of hope in the desert of antibiotic side effects. The researchers found that septic patients receiving both linezolid and vitamin B6 showed positive effects on some hematologic parameters, particularly RBC, Hb, and Hct. This suggests that vitamin B6 could potentially help mitigate some of the hematologic side effects associated with linezolid treatment.

Navigating the Desert of Antibiotic Treatment: Minimizing Side Effects

This study highlights the importance of minimizing the side effects of antibiotic treatment. The findings suggest that vitamin B6 could play a role in mitigating some of the hematologic side effects associated with linezolid. This research provides valuable insights for clinicians managing septic patients receiving linezolid treatment.

Dr.Camel's Conclusion

This study provides evidence for the potential benefit of vitamin B6 in mitigating some of the hematologic side effects associated with linezolid. It's like finding a hidden oasis in the desert of antibiotic side effects, offering a chance to improve the well-being of patients receiving linezolid treatment.

Date :
  1. Date Completed 2014-01-03
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24385027

DOI: Digital Object Identifier

PMC3862191

Related Literature

Article Analysis
・Effects of linezolid
SNS
PICO Info
in preparation
Languages

English

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