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Iron chelation and multiple sclerosis.

Author: LeVineSteven M, LynchSharon G, WeigelKelsey J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Iron accumulation in the brain is linked to multiple sclerosis (MS). Iron chelation therapy could be beneficial, as it has shown promise in animal models and preliminary studies with deferoxamine. While some side effects occurred, they were manageable. Deferiprone, an oral chelator that crosses the blood-brain barrier, could be a better option for MS patients, but close monitoring is essential.
Paper Details　
Original Abstract of the Article :
Histochemical and MRI studies have demonstrated that MS (multiple sclerosis) patients have abnormal deposition of iron in both gray and white matter structures. Data is emerging indicating that this iron could partake in pathogenesis by various mechanisms, e.g., promoting the production of reactive ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906635/

データ提供：米国国立医学図書館（NLM）

Iron Chelation: A Potential Therapeutic Strategy for Multiple Sclerosis

Multiple sclerosis (MS) is a complex neurological disorder characterized by abnormal iron deposition in both gray and white matter structures. This study explores the potential of iron chelation therapy as a treatment strategy for MS. The researchers examined the role of iron in MS pathogenesis and the potential benefits of iron chelation therapy. The study highlights the potential benefits of iron chelation in preventing iron-related pathological events and protecting cells from damage caused by iron buildup. The study reviewed existing research on iron chelation therapy for MS, including preclinical studies in animal models and preliminary clinical trials. They found that iron chelation therapy could be a viable option for MS treatment, but further research is needed to determine its efficacy and safety.

Iron's Role in Multiple Sclerosis

This study sheds light on the complex relationship between iron and MS. Imagine a desert ecosystem – iron is an essential mineral, but an excess of it can be detrimental. This study suggests that iron, while essential, may contribute to the pathogenesis of MS. The study provides a compelling argument for exploring the use of iron chelation therapy as a potential treatment strategy.

Iron Chelation: A Promising Avenue for MS Research

This study underscores the potential of iron chelation as a therapeutic target for MS. It's like finding a hidden oasis in the vast desert of MS research – iron chelation offers a promising avenue for exploring new treatments. While more research is needed, this study lays the groundwork for future investigations into this potentially impactful therapy.

Dr. Camel's Conclusion

This research explores the potential of iron chelation therapy as a treatment strategy for MS. It highlights the role of iron in MS pathogenesis and suggests that iron chelation may offer a promising avenue for future therapeutic development. Further research is needed to determine the efficacy and safety of iron chelation therapy for MS, but the findings suggest that it may be a viable option for treating this debilitating condition.
Date :
  1. Date Completed 2014-12-23
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24397846

DOI: Digital Object Identifier

PMC3906635

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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