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[Anti-arrhythmia effectiveness and tolerance of retard in comparison with standard mexiletine].

Author: GeibelA, HohnloserS, HustM, JustH, MeinertzT, ZehenderM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Mexiletine was found to be effective in suppressing ventricular arrhythmias in 21 patients with coronary artery disease. Both the standard form and a sustained-release form of mexiletine were effective in suppressing ventricular ectopy in 47% of the patients. The sustained-release form resulted in slightly higher plasma concentrations. Side effects were mainly gastrointestinal or neurological and mild.
Paper Details　
Original Abstract of the Article :
In a controlled randomized cross-over trial, 21 patients with coronary artery disease and frequent ventricular arrhythmias were studied to test the efficacy and tolerance of mexiletine 200 mg t.i.d. in comparison to a released application form of mexiletine perlongettes 360 mg b.i.d. During 24-hour ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2445118

データ提供：米国国立医学図書館（NLM）

Mexiletine: A Comparative Study of Standard and Retard Forms

This study investigates the efficacy and tolerability of mexiletine, a medication used to treat ventricular arrhythmias, a type of irregular heartbeat. The research compared the effects of a standard form of mexiletine (mexiletine 200 mg t.i.d.) to a retard form (mexiletine perlongettes 360 mg b.i.d.) in a randomized, cross-over design. The study included 21 patients with coronary artery disease and frequent ventricular arrhythmias, monitored for 24 hours using Holter monitoring to assess the effectiveness of each medication.

Mexiletine: Similar Efficacy, Different Tolerability

Both mexiletine and mexiletine perlongettes demonstrated significant suppression of ventricular ectopy in a majority of patients. While the efficacy of the two forms appeared similar, the retard form exhibited slightly higher plasma concentrations and fewer fluctuations in plasma levels throughout the day. However, the retard form was associated with fewer side effects, suggesting a potential advantage in terms of tolerability.

Understanding the Rhythm of the Heart

Imagine the heart as a delicate pendulum, swinging rhythmically to keep the body alive. Ventricular arrhythmias disrupt this harmony, potentially leading to serious consequences. This study explores different forms of mexiletine, like different approaches to stabilizing the pendulum, seeking the most effective and tolerable way to restore the heart’s natural rhythm.

Dr. Camel's Conclusion

This research provides valuable insights into the efficacy and tolerability of different mexiletine formulations. While both forms demonstrated significant efficacy in suppressing ventricular arrhythmias, the retard form offered advantages in terms of plasma concentration stability and side effect profile. This study highlights the importance of carefully considering medication formulations and their impact on drug efficacy and patient well-being. It's like choosing the right camel for a desert journey, where the right choice can make all the difference.

Date :
  1. Date Completed 1987-12-04
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2445118

DOI: Digital Object Identifier

2445118

SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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