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Oligodendrogenesis and myelinogenesis during postnatal development effect of glatiramer acetate.

Author: AharoniRina, ArnonRuth, Bar-LevDekel D, EilamRaya, FromRenana, Levin-ZaidmanSmadar, LoPrestiPatrizia, SelaMichael, TsooryMichael

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Glatiramer acetate (GA), a drug used to treat multiple sclerosis (MS), has been shown to have a beneficial effect on oligodendrogenesis and myelination. In this study, daily injections of GA in mice from postnatal days 7-21 resulted in significant increases in the number of myelinated axons, myelin thickness, and axonal diameter compared to control mice. These effects were linked to increased proliferation and differentiation of oligodendrocytes, as well as increased levels of IGF-1 and BDNF.
Paper Details　
Original Abstract of the Article :
Myelinogenesis in the mammal nervous system occurs predominantly postnatally. Glatiramer acetate (GA), a drug for the treatment for multiple sclerosis (MS), has been shown to induce immunomodulation and neuroprotection in the inflamed CNS in MS and in experimental autoimmune encephalomyelitis (EAE)....See full text at original site
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引用元：
https://doi.org/10.1002/glia.22632

データ提供：米国国立医学図書館（NLM）

The Role of Glatiramer Acetate in Myelinogenesis

We embark on a journey into the fascinating world of neurobiology, focusing on the vital process of myelinogenesis. This study explores the role of glatiramer acetate (GA), a drug used to treat multiple sclerosis, in promoting myelin formation, the protective sheath that insulates nerve fibers. The researchers investigated whether GA could influence myelinogenesis and oligodendrogenesis, the process of creating myelin-producing cells, in the developing nervous system.

GA: A Catalyst for Myelin Formation

The study revealed that GA significantly enhanced myelin formation, leading to increased myelinated axons and thicker myelin sheaths. These findings suggest that GA plays a pivotal role in promoting myelinogenesis, potentially offering therapeutic benefits for diseases affecting the nervous system.

The Power of Myelin: A Key to Nerve Health

This research highlights the importance of myelin in maintaining healthy nerve function. Understanding the mechanisms behind myelin formation and its role in neurological health can pave the way for new therapeutic approaches to neurodegenerative diseases.

Dr.Camel's Conclusion

This research reveals that GA, a drug used to treat multiple sclerosis, can also promote myelin formation in the developing nervous system. This is a significant finding, as it may lead to new treatments for a variety of neurodegenerative diseases. The desert of neurology is vast and complex, but this research shines a light on the importance of myelin and its potential for therapeutic intervention.

Date :
  1. Date Completed 2023-02-14
  2. Date Revised 2023-02-14
Further Info :

Pubmed ID

24481644

DOI: Digital Object Identifier

10.1002/glia.22632

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・Effects of glatiramer injection
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PICO Info
in preparation
Languages

English

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