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Blockade of 5-Ht3 receptors in the septal area increases Fos expression in selected brain areas.

Author: FerreiraHilda S, FregonezeJosmara B, LuzCarla Patrícia, PerroneCamila F, SantanaRejane Conceição, Urzedo-RodriguesLilia S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the neuronal circuitry involved in the hypertensive response induced by ondansetron, a 5-HT3 receptor antagonist, in rats. Injection of ondansetron into the medial septum/vertical limb of the diagonal band complex (MS/vDB) increased Fos-IR in various brain areas, including the limbic system, hypothalamus, mesencephalon, and rhombencephalon. The findings suggest that 5-HT3 receptors in the MS/vDB exert an inhibitory drive on blood pressure regulation.
Paper Details　
Original Abstract of the Article :
Serotonin is widely distributed throughout the brain and is involved in a multiplicity of visceral, cognitive and behavioral responses. It has been previously shown that injections of different doses of ondansetron, a 5-HT3 receptor antagonist, into the medial septum/vertical limb of the diagonal ba...See full text at original site
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引用元：
https://doi.org/10.1016/j.autneu.2014.01.003

データ提供：米国国立医学図書館（NLM）

Exploring the Labyrinth of Brain Activity

The human brain is a vast and intricate network, and serotonin plays a crucial role in its many functions. This research delves into the complex interplay between serotonin and blood pressure, exploring the role of 5-HT3 receptors in the septal area of the brain. Like a desert explorer venturing into a labyrinth, researchers used sophisticated techniques to investigate the impact of blocking these receptors on brain activity. Their findings revealed a complex interplay between 5-HT3 receptors and blood pressure regulation, highlighting the intricate connections within the brain.

Unveiling the Secrets of the Brain

The study's findings suggest that 5-HT3 receptors in the septal area of the brain play a significant role in regulating blood pressure. The researchers observed that blocking these receptors led to increased activity in various brain regions, highlighting their importance in the complex network that controls blood pressure. It's like discovering a hidden chamber within a desert labyrinth, revealing a new aspect of the brain's intricate system.

The Desert of the Brain

The human brain is a vast and mysterious desert. This study provides valuable insights into the intricate connections within this intricate network, helping us understand how serotonin and 5-HT3 receptors contribute to the regulation of vital functions like blood pressure.

Dr.Camel's Conclusion

This research serves as a reminder of the complexities of the human brain. It's like a desert explorer uncovering a hidden oasis, revealing a new aspect of the intricate network that governs our bodies.

Date :
  1. Date Completed 2014-11-03
  2. Date Revised 2014-02-21
Further Info :

Pubmed ID

24507935

DOI: Digital Object Identifier

10.1016/j.autneu.2014.01.003

Related Literature

Article Analysis
・Effects of ondansetron injection
SNS
PICO Info
in preparation
Languages

English

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