Synthesis, spectroscopic and DFT structural characterization of two novel ruthenium(III) oxicam complexes. In vivo evaluation of anti-inflammatory and gastric damaging activities.

Author: BerniniCaterina, CiniRenzo, CorbiniGianfranco, GiudicePietro Lo, MassaiLara, MessoriLuigi, OwensNatalie F, ScalettiFederica, TamasiGabriella

Paper Details 
Original Abstract of the Article :
The reactions of ruthenium(III) chloride trihydrate with piroxicam (H2PIR) and tenoxicam (H2TEN), two widely used non-steroidal anti-inflammatory drugs, afforded [Ru(III)Cl2(H2PIR)(HPIR)],·1, and [Ru(III)Cl2(H2TEN)(HTEN)],·2. Both compounds were obtained as pure green solids through purification via...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.jinorgbio.2014.01.011

データ提供:米国国立医学図書館(NLM)

Improving Oxicam Drugs: A New Approach to Anti-Inflammatory Treatment

The search for better and safer [anti-inflammatory] treatments is an ongoing journey, like seeking a more effective and less harsh path through a desert landscape. This study explores the potential of [ruthenium(III) coordination complexes] to enhance the properties of [oxicam drugs], two widely used non-steroidal anti-inflammatory drugs (NSAIDs). It's like discovering a new oasis in the desert of anti-inflammatory therapy, offering a potential solution for improving therapeutic efficacy and reducing side effects.

The authors synthesized and characterized two new [ruthenium(III) oxicam complexes], investigating their anti-inflammatory activity and gastrointestinal toxicity. They sought to evaluate the potential of these coordination complexes to enhance the therapeutic properties of [oxicam drugs], potentially offering a safer and more effective approach to anti-inflammatory treatment.

A New Oasis in the Desert of Anti-Inflammatory Therapy

This study provides promising results for the development of improved [oxicam drugs], suggesting that [ruthenium(III) coordination complexes] could enhance their therapeutic efficacy and reduce their gastrointestinal side effects. This research is like finding a new oasis in the desert of anti-inflammatory therapy, offering a potential solution for improving patient outcomes and reducing the burden of gastrointestinal complications associated with NSAID use.

Navigating the Desert of NSAID Treatment

This research highlights the potential of [ruthenium(III) coordination complexes] to improve the safety and efficacy of [oxicam drugs]. It's like finding a new path through the desert of NSAID treatment, offering a more effective and less harsh approach to managing pain and inflammation. This research underscores the importance of continued innovation in the field of anti-inflammatory therapy, seeking to optimize therapeutic outcomes and minimize side effects.

Dr. Camel's Conclusion

This study presents a compelling case for the development of improved [oxicam drugs] using [ruthenium(III) coordination complexes]. The authors' research offers a potential solution for enhancing therapeutic efficacy while reducing gastrointestinal side effects, offering a brighter future for patients seeking effective and safe treatment options. This research is like finding a new oasis in the desert of anti-inflammatory therapy, providing a promising path towards improved patient care.

Date :
  1. Date Completed 2014-11-24
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

24518539

DOI: Digital Object Identifier

10.1016/j.jinorgbio.2014.01.011

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.