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Synthesis, spectroscopic and DFT structural characterization of two novel ruthenium(III) oxicam complexes. In vivo evaluation of anti-inflammatory and gastric damaging activities.
Author: BerniniCaterina, CiniRenzo, CorbiniGianfranco, GiudicePietro Lo, MassaiLara, MessoriLuigi, OwensNatalie F, ScalettiFederica, TamasiGabriella
Original Abstract of the Article :
The reactions of ruthenium(III) chloride trihydrate with piroxicam (H2PIR) and tenoxicam (H2TEN), two widely used non-steroidal anti-inflammatory drugs, afforded [Ru(III)Cl2(H2PIR)(HPIR)],·1, and [Ru(III)Cl2(H2TEN)(HTEN)],·2. Both compounds were obtained as pure green solids through purification via...See full text at original site
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引用元:
https://doi.org/10.1016/j.jinorgbio.2014.01.011
データ提供:米国国立医学図書館(NLM)
Improving Oxicam Drugs: A New Approach to Anti-Inflammatory Treatment
The search for better and safer [anti-inflammatory] treatments is an ongoing journey, like seeking a more effective and less harsh path through a desert landscape. This study explores the potential of [ruthenium(III) coordination complexes] to enhance the properties of [oxicam drugs], two widely used non-steroidal anti-inflammatory drugs (NSAIDs). It's like discovering a new oasis in the desert of anti-inflammatory therapy, offering a potential solution for improving therapeutic efficacy and reducing side effects.
The authors synthesized and characterized two new [ruthenium(III) oxicam complexes], investigating their anti-inflammatory activity and gastrointestinal toxicity. They sought to evaluate the potential of these coordination complexes to enhance the therapeutic properties of [oxicam drugs], potentially offering a safer and more effective approach to anti-inflammatory treatment.
A New Oasis in the Desert of Anti-Inflammatory Therapy
This study provides promising results for the development of improved [oxicam drugs], suggesting that [ruthenium(III) coordination complexes] could enhance their therapeutic efficacy and reduce their gastrointestinal side effects. This research is like finding a new oasis in the desert of anti-inflammatory therapy, offering a potential solution for improving patient outcomes and reducing the burden of gastrointestinal complications associated with NSAID use.
Navigating the Desert of NSAID Treatment
This research highlights the potential of [ruthenium(III) coordination complexes] to improve the safety and efficacy of [oxicam drugs]. It's like finding a new path through the desert of NSAID treatment, offering a more effective and less harsh approach to managing pain and inflammation. This research underscores the importance of continued innovation in the field of anti-inflammatory therapy, seeking to optimize therapeutic outcomes and minimize side effects.
Dr. Camel's Conclusion
This study presents a compelling case for the development of improved [oxicam drugs] using [ruthenium(III) coordination complexes]. The authors' research offers a potential solution for enhancing therapeutic efficacy while reducing gastrointestinal side effects, offering a brighter future for patients seeking effective and safe treatment options. This research is like finding a new oasis in the desert of anti-inflammatory therapy, providing a promising path towards improved patient care.
Date :
- Date Completed 2014-11-24
- Date Revised 2016-11-25
Further Info :
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