The roles of BDNF, S100B, and oxidative stress in interferon-induced depression and the effect of antidepressant treatment in patients with chronic viral hepatitis: a prospective study.

Author: CicekErdinc, CicekIsmet Esra, EraymanIbrahim, KayaNazmiye, KayhanFatih, KurbanSevil, UguzFaruk, YerlikayaF Hümeyra

Paper Details 
Original Abstract of the Article :
OBJECTIVE: The aim of the study was to research the relationship between interferon (IFN) induced depression and sociodemographic characteristics, neurotrophic factors and oxidative stress. METHODS: Sixty four cases, 34 with Chronic Hepatitis B (CHB) and 30 with Chronic Hepatitis C (CHC), were incl...See full text at original site
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引用元:
https://doi.org/10.1016/j.jpsychores.2014.01.003

データ提供:米国国立医学図書館(NLM)

Interferon-Induced Depression: Exploring the Desert of Mental Health

Interferon (IFN) therapy is a powerful tool in the fight against viral infections, but it can sometimes have unexpected side effects. This study delves into the intricate world of interferon-induced depression, investigating the relationship between IFN therapy, neurotrophic factors, and oxidative stress. The researchers found that IFN therapy was associated with significant changes in levels of brain-derived neurotrophic factor (BDNF) and S100B, suggesting potential roles of these factors in the development of depression. This research is like exploring a hidden canyon in the desert of mental health, revealing the complex interplay between IFN therapy, neurotrophic factors, and depression.

Neurotrophic Factors and Depression: Unveiling the Hidden Canyons

The study found that interferon (IFN) therapy was associated with significant changes in levels of brain-derived neurotrophic factor (BDNF) and S100B, both of which play crucial roles in brain health. This discovery suggests that these factors may be involved in the development of depression following IFN therapy. It's like finding a network of hidden canyons in the desert of mental health, revealing the intricate pathways that connect IFN therapy, neurotrophic factors, and depression.

Navigating the Desert of Mental Health

This research underscores the importance of monitoring patients receiving IFN therapy for signs of depression and considering potential interventions to mitigate the risk. It's a reminder that the desert of mental health is complex and often hidden from view. This study encourages us to be vigilant in identifying and addressing potential mental health complications associated with medical treatments, ensuring that patients receive the best possible care throughout their journey.

Dr. Camel's Conclusion

This research takes us on a journey through the vast desert of mental health, exploring the intricate relationship between interferon therapy, neurotrophic factors, and depression. The study reveals the complex interplay of these factors, highlighting the need for continued research and improved understanding of these connections. It's a reminder that the desert of medicine is full of hidden oases, waiting to be discovered, and we must always be vigilant in our quest for knowledge and better care for those who need it most.

Date :
  1. Date Completed 2014-10-16
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

24529042

DOI: Digital Object Identifier

10.1016/j.jpsychores.2014.01.003

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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